Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3222848 | 0.88 | SCD (0.61) | MAPTALDH1A1KDM4E | |
| SCHEMBL20241864 | 0.81 | SHMT1 (0.64) | MAPTCYP2C9CYP2C19ALDH1A1MEN1 | |
| SCHEMBL3547359 | 0.80 | MAPT (0.80) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4636133 | 0.80 | MAPT (0.70) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3208628 | 0.79 | SMN1; SMN2 (0.55) | MAPTCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL12310175 | 0.75 | TP53 (0.79) | MAPTMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL16607167 | 0.74 | MAPT (1.00) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3209227 | 0.74 | RAB9A (0.65) | MAPTCYP1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL2656561 | 0.73 | MAPK1 (0.77) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3611202 | 0.73 | ALDH1A1 (0.88) | MAPTCYP2C9CYP2C19ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683097-B2 | Topoisomerase inhibitors | Propharmacon Inc. (US) | 2010-03-23 | — | — | US | claimed |