Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.49 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3216021 | 0.89 | HSD11B1 (0.67) | HSD11B1TRPV1HTR1AHTR7 | |
| SCHEMBL3207553 | 0.85 | HSD11B1 (0.50) | HSD11B1TRPV1 | |
| SCHEMBL4486904 | 0.85 | HSD11B1 (0.67) | HSD11B1TRPV1 | |
| SCHEMBL3210332 | 0.85 | HSD11B1 (0.68) | HSD11B1TRPV1 | |
| SCHEMBL3217891 | 0.83 | HSD11B1 (0.52) | HSD11B1TRPV1EPHX2 | |
| SCHEMBL3221211 | 0.83 | HSD11B1 (0.65) | HSD11B1TRPV1 | |
| SCHEMBL3223132 | 0.82 | HSD11B1 (0.66) | HSD11B1TRPV1 | |
| SCHEMBL3216358 | 0.78 | HSD11B1 (0.53) | HSD11B1TRPV1HTR1AHTR7 | |
| SCHEMBL14018578 | 0.74 | EPHX2 (0.59) | HSD11B1TRPV1EPHX2 | |
| SCHEMBL12317612 | 0.74 | HTR2A (0.59) | HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | HSD11B1 1/4885TRPV1 4793/4885KIF18A 4050/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885TRPV1 4707/4885KIF18A 4117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.