Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3210332 | 0.86 | HSD11B1 (0.68) | HSD11B1TRPV1 | |
| SCHEMBL3209159 | 0.85 | HSD11B1 (0.53) | HSD11B1TRPV1 | |
| SCHEMBL3217891 | 0.85 | HSD11B1 (0.52) | HSD11B1TRPV1 | |
| SCHEMBL3221195 | 0.85 | HSD11B1 (0.70) | HSD11B1NPSR1HSD17B10 | |
| SCHEMBL3221211 | 0.85 | HSD11B1 (0.65) | HSD11B1TRPV1 | |
| SCHEMBL3207553 | 0.84 | HSD11B1 (0.50) | HSD11B1TRPV1 | |
| SCHEMBL3216021 | 0.84 | HSD11B1 (0.67) | HSD11B1TRPV1 | |
| SCHEMBL3223132 | 0.83 | HSD11B1 (0.66) | HSD11B1TRPV1 | |
| SCHEMBL3213169 | 0.80 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL3216358 | 0.80 | HSD11B1 (0.53) | HSD11B1ALDH1A1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885NPSR1 1342/4885HSD17B10 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.