Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 6/20 | 0.35 |
| ▸ | AQP1 | P29972 | 2/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR5A | P47898 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3208813 | 1.00 | HTR2C (0.36) | HTR2CHTR2AHTR2BPBRM1AQP1 | |
| SCHEMBL3203168 | 1.00 | HTR2C (0.36) | HTR2CHTR2AHTR2BPBRM1AQP1 | |
| SCHEMBL3218216 | 0.94 | AQP1 (0.36) | HTR2CHTR2AHTR2BAQP1PRKAB2 | |
| SCHEMBL3222302 | 0.94 | AQP1 (0.36) | HTR2CHTR2AHTR2BAQP1PRKAB2 | |
| SCHEMBL3212268 | 0.94 | AQP1 (0.36) | HTR2CHTR2AHTR2BAQP1PRKAB2 | |
| SCHEMBL3218165 | 0.91 | PRKAB2 (0.34) | HTR2CHTR2AHTR2BPRKAB2PRKAG1 | |
| SCHEMBL3213753 | 0.91 | PRKAB2 (0.34) | HTR2CHTR2AHTR2BPRKAB2PRKAG1 | |
| SCHEMBL3218102 | 0.91 | PRKAB2 (0.34) | HTR2CHTR2AHTR2BPRKAB2PRKAG1 | |
| SCHEMBL3207333 | 0.88 | AQP1 (0.33) | HTR2CHTR2AHTR2BPBRM1AQP1 | |
| SCHEMBL3214846 | 0.88 | AQP1 (0.33) | HTR2CHTR2AHTR2BPBRM1AQP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035871-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | WYETH | 2010-02-11 | — | — | US | claimed |
| WO-2008052075-A2 | BENZOXAZINE DERIVATIVES AND USES THEREOF | WYETH (US) | 2008-05-02 | — | — | WO | claimed |
| WO-2008052075-A2 | BENZOXAZINE DERIVATIVES AND USES THEREOF | WYETH (US) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035871-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | HTR2C, HTR5A, NPY1R | HTR2C 1/4885HTR2A 5/4885HTR2B 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.