Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3260049 | 0.89 | CYP2D6 (0.95) | CYP2D6CYP2C19CYP1A2RECQLALDH1A1 | |
| SCHEMBL3207575 | 0.88 | CYP2D6 (0.97) | CYP2D6CYP2C19CYP1A2RECQLALDH1A1 | |
| SCHEMBL6323061 | 0.85 | LMNA (0.78) | ALDH1A1KMT2AMEN1HTTLMNA | |
| SCHEMBL12694371 | 0.81 | POLB (0.75) | CYP2C19ALDH1A1CYP2C9KMT2AMEN1 | |
| SCHEMBL1353693 | 0.80 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1HTTLMNA | |
| SCHEMBL25522803 | 0.80 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1HTTLMNA | |
| SCHEMBL3203453 | 0.80 | ALDH1A1 (0.72) | ALDH1A1KMT2AMEN1HTTLMNA | |
| SCHEMBL17896865 | 0.80 | ALDH1A1 (0.82) | ALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL16096264 | 0.80 | KMT2A (0.69) | ALDH1A1KMT2AMEN1HTTLMNA | |
| SCHEMBL4577546 | 0.79 | ALDH1A1 (0.72) | CYP2D6CYP2C19CYP1A2RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048891-A1 | METASUBSTITUTED THIAZOLIDINONES, THEIR MANUFACTURE AND USE AS A DRUG | SCHULZE KLAUSE | 2010-02-25 | — | — | US | disclosed |
| US-20100048891-A1 | METASUBSTITUTED THIAZOLIDINONES, THEIR MANUFACTURE AND USE AS A DRUG | SCHULZE KLAUSE | 2010-02-25 | — | — | US | disclosed |
| US-20070015759-A1 | Metasubstituted thiazolidinones, their manufacture and use as a drug | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048891-A1 | METASUBSTITUTED THIAZOLIDINONES, THEIR MANUFACTURE AND USE AS A DRUG | PLK2, PDXK, PLK4 | CYP2D6 731/4885CYP2C19 1086/4885CYP1A2 1451/4885 |
| US-20070015759-A1 | Metasubstituted thiazolidinones, their manufacture and use as a drug | PLK4, PDXK, PLK2 | CYP2D6 273/4885CYP2C19 334/4885CYP1A2 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.