Sugi Predict

Sugi Predict / Compounds / SCHEMBL3215934

SCHEMBL3215934

SCHEMBL3215934

Clc1ccc(-c2cccn3cncc23)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ QPCT Q16769 1/20 0.66
▸ QPCTL Q9NXS2 1/20 0.66
▸ ALDH1A3 P47895 2/20 0.46
▸ ALDH1A2 O94788 1/20 0.46
▸ KDM4E B2RXH2 5/20 0.42
▸ RAB9A P51151 5/20 0.42
▸ NPC1 O15118 4/20 0.42
▸ ALDH1A1 P00352 4/20 0.42
▸ MAPT P10636 2/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ IDO1 P14902 2/20 0.40
▸ CYP17A1 P05093 1/20 0.39
▸ TDO2 P48775 1/20 0.38
▸ PKM P14618 1/20 0.38
▸ TBXAS1 P24557 1/20 0.38
▸ GAA P10253 2/20 0.37
▸ MEN1 O00255 2/20 0.36
▸ HPGD P15428 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ CYP11B1 P15538 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12698760 0.85 QPCT (0.68) QPCTQPCTLALDH1A3ALDH1A2ALDH1A1
SCHEMBL3260750 0.84 QPCT (0.67) QPCTQPCTLALDH1A3ALDH1A2IDO1
SCHEMBL3231053 0.83 QPCT (0.66) QPCTQPCTLALDH1A3KDM4ERAB9A
SCHEMBL3228833 0.83 QPCT (0.54) QPCTQPCTLRAB9ANPC1IDO1
SCHEMBL3225502 0.80 QPCT (1.00) QPCTQPCTLKDM4ERAB9ANPC1
SCHEMBL9656910 0.78 QPCT (0.59) QPCTQPCTLALDH1A3ALDH1A2KDM4E
SCHEMBL3224883 0.78 QPCT (0.51) QPCTQPCTLKDM4ERAB9ANPC1
SCHEMBL12698831 0.78 QPCT (0.59) QPCTQPCTLALDH1A3ALDH1A2IDO1
SCHEMBL3224645 0.76 QPCT (0.72) QPCTQPCTLKDM4ERAB9ANPC1
SCHEMBL4855392 0.74 IDO1 (0.47) QPCTQPCTLIDO1CYP17A1TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2118101-B1 IMIDAZO [1,5-A] PYRIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2012-09-26 — — EP claimed
US-7803810-B2 Inhibitors PROBIODRUG AG (DE) 2010-09-28 — — US claimed
US-20080234313-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2008-09-25 — — US claimed
EP-2118101-B1 IMIDAZO [1,5-A] PYRIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2012-09-26 — — EP disclosed
US-7803810-B2 Inhibitors PROBIODRUG AG (DE) 2010-09-28 — — US disclosed
US-7803810-B2 Inhibitors PROBIODRUG AG (DE) 2010-09-28 — — US disclosed
US-7803810-B2 Inhibitors PROBIODRUG AG (DE) 2010-09-28 — — US disclosed
US-20080234313-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2008-09-25 — — US disclosed
US-20080234313-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2008-09-25 — — US disclosed
US-20080234313-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2008-09-25 — — US disclosed
WO-2008110523-A1 IMIDAZO [1,5-A] PYRIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2008-09-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080234313-A1 NOVEL INHIBITORS SF3A1, HBS1L, SF3A3 QPCT 4475/4885QPCTL 4381/4885ALDH1A3 1718/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.