Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 1/20 | 0.67 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.67 |
| ▸ | IDO1 | P14902 | 3/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.45 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | EED | O75530 | 2/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | MST1R | Q04912 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12698760 | 0.96 | QPCT (0.68) | QPCTQPCTLIDO1TDO2ALDH1A3 | |
| SCHEMBL12698831 | 0.93 | QPCT (0.59) | QPCTQPCTLIDO1TDO2ALDH1A3 | |
| SCHEMBL12698953 | 0.89 | QPCT (0.55) | QPCTQPCTLIDO1TDO2ALDH1A3 | |
| SCHEMBL3215934 | 0.84 | QPCT (0.66) | QPCTQPCTLIDO1TDO2ALDH1A3 | |
| SCHEMBL3231053 | 0.84 | QPCT (0.66) | QPCTQPCTLIDO1TDO2ALDH1A3 | |
| SCHEMBL9656910 | 0.82 | QPCT (0.59) | QPCTQPCTLIDO1TDO2ALDH1A3 | |
| SCHEMBL12698832 | 0.82 | QPCT (0.49) | QPCTQPCTLIDO1TDO2TBXAS1 | |
| SCHEMBL3229481 | 0.80 | QPCT (0.54) | QPCTQPCTLIDO1TDO2TBXAS1 | |
| SCHEMBL3225502 | 0.80 | QPCT (1.00) | QPCTQPCTLCYP11B2CYP11B1CYP17A1 | |
| SCHEMBL3228833 | 0.80 | QPCT (0.54) | QPCTQPCTLIDO1TDO2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118101-B1 | IMIDAZO [1,5-A] PYRIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2012-09-26 | — | — | EP | claimed |
| US-7803810-B2 | Inhibitors | PROBIODRUG AG (DE) | 2010-09-28 | — | — | US | claimed |
| EP-2118101-A1 | IMIDAZO [1,5-A] PYRIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE | Probiodrug AG (DE) | 2009-11-18 | — | — | EP | claimed |
| US-20080234313-A1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2008-09-25 | — | — | US | claimed |
| WO-2008110523-A1 | IMIDAZO [1,5-A] PYRIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2008-09-18 | — | — | WO | claimed |
| WO-2018136887-A1 | COMPOUNDS | TESARO, INC. (US) | 2018-07-26 | — | — | WO | disclosed |
| EP-2118101-B1 | IMIDAZO [1,5-A] PYRIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2012-09-26 | — | — | EP | disclosed |
| EP-2118101-B1 | IMIDAZO [1,5-A] PYRIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2012-09-26 | — | — | EP | disclosed |
| US-7803810-B2 | Inhibitors | PROBIODRUG AG (DE) | 2010-09-28 | — | — | US | disclosed |
| US-7803810-B2 | Inhibitors | PROBIODRUG AG (DE) | 2010-09-28 | — | — | US | disclosed |
| US-7803810-B2 | Inhibitors | PROBIODRUG AG (DE) | 2010-09-28 | — | — | US | disclosed |
| EP-2118101-A1 | IMIDAZO [1,5-A] PYRIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE | Probiodrug AG (DE) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008110523-A1 | IMIDAZO [1,5-A] PYRIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2008-09-18 | — | — | WO | disclosed |
| US-5171858-A | Preparation of certain 5,6-dihydro-8-phenyl-imidazo[1,5-a]pyridines | SCHERING A.G. (DE) | 1992-12-15 | — | — | US | disclosed |
| US-5171858-A | Preparation of certain 5,6-dihydro-8-phenyl-imidazo[1,5-a]pyridines | SCHERING A.G. (DE) | 1992-12-15 | — | — | US | disclosed |
| US-5171859-A | Certain 2-aminomethyl-3-phenyl-pyridine intermediates for certain 8-phenyl-imidazo[1,5-a]pyridines | SCHERING A.G. (DE) | 1992-12-15 | — | — | US | disclosed |
| US-5171859-A | Certain 2-aminomethyl-3-phenyl-pyridine intermediates for certain 8-phenyl-imidazo[1,5-a]pyridines | SCHERING A.G. (DE) | 1992-12-15 | — | — | US | disclosed |
| US-5171859-A | Certain 2-aminomethyl-3-phenyl-pyridine intermediates for certain 8-phenyl-imidazo[1,5-a]pyridines | SCHERING A.G. (DE) | 1992-12-15 | — | — | US | disclosed |
| US-5026712-A | Novel imidazo[1,5-a]pyridines, useful as cardiovascular and CNS agents | SCHERING AG (DE) | 1991-06-25 | — | — | US | disclosed |
| US-5026712-A | Novel imidazo[1,5-a]pyridines, useful as cardiovascular and CNS agents | SCHERING AG (DE) | 1991-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234313-A1 | NOVEL INHIBITORS | SF3A1, HBS1L, SF3A3 | QPCT 4475/4885QPCTL 4381/4885IDO1 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.