SCHEMBL3216136

SCHEMBL3216136

Oc1cc2cc(I)cnc2cc1F

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 4/20 0.38
PDGFRA P16234 4/20 0.38
EGFR P00533 2/20 0.38
TET2 Q6N021 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22326627 0.84 PDGFRB (0.46) PDGFRBPDGFRATET2
SCHEMBL3217581 0.78 PDGFRB (0.38) PDGFRBPDGFRAEGFR
SCHEMBL18571995 0.70 PDGFRB (0.38) PDGFRBPDGFRAEGFR
SCHEMBL28811662 0.69 BACE1 (0.41) PDGFRBPDGFRA
SCHEMBL535151 0.69 MAP4K4 (0.46) PDGFRBPDGFRA
SCHEMBL25911367 0.68 ALDH1A1 (0.53) PDGFRBPDGFRA
SCHEMBL18848508 0.67 NOS1 (0.42) PDGFRBPDGFRAEGFR
SCHEMBL19021347 0.67 MGAM (0.51) PDGFRBPDGFRAEGFR
Bromide SCHEMBL18987913 0.66 MGAM (0.50) PDGFRBPDGFRAEGFR
Hydrochloric Acid SCHEMBL18987456 0.66 MGAM (0.50) PDGFRBPDGFRAEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101522030-B Fungicides SYNGENTA PARTICIPATIONS AG 2012-09-05 CN disclosed
US-20100056570-A1 FUNGICIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-03-04 US disclosed
CN-101522030-A Fungicides SYNGENTA PARTICIPATIONS AG (CH) 2009-09-02 CN disclosed
EP-2068632-A1 FUNGICIDES Syngeta Participations AG (CH) 2009-06-17 EP disclosed
WO-2008028624-A1 FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2008-03-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056570-A1 FUNGICIDES CYP21A2, CYP51A1, CYP4X1 PDGFRB 4516/4885PDGFRA 4427/4885EGFR 4223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.