Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6903631 | 0.85 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ATDP1TERT | |
| SCHEMBL7527729 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2ATDP1KDM4E | |
| SCHEMBL96214 | 0.78 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2ATDP1HSP90AA1 | |
| SCHEMBL28162291 | 0.76 | DYRK1A (0.41) | ALDH1A1MEN1KMT2ATDP1DYRK1A | |
| SCHEMBL29954526 | 0.76 | TSHR (0.54) | ALDH1A1MEN1KMT2ATDP1CA1 | |
| SCHEMBL29955549 | 0.76 | ERN1 (0.38) | ALDH1A1MEN1KMT2ATDP1CA1 | |
| SCHEMBL29953764 | 0.76 | ERN1 (0.41) | ALDH1A1MEN1KMT2ATDP1CA1 | |
| SCHEMBL28738488 | 0.76 | TSHR (0.54) | ALDH1A1MEN1KMT2ATDP1CA1 | |
| SCHEMBL7530450 | 0.76 | ERN1 (0.38) | ALDH1A1MEN1KMT2ATDP1CA1 | |
| SCHEMBL28806185 | 0.75 | ALDH1A1 (0.94) | ALDH1A1MEN1KMT2ATDP1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107382820-A | A kind of synthetic method of 3 arylisoindole derivative | 常州大学 | 2017-11-24 | — | — | CN | claimed |
| CN-105111217-A | Method for synthesizing isoindole dihyroquinazoline derivative | UNIV CHANGZHOU | 2015-12-02 | — | — | CN | claimed |
| CN-104876850-A | Isoindolinone derivative synthesis method | UNIV CHANGZHOU | 2015-09-02 | — | — | CN | claimed |
| CN-116283810-B | Preparation method of isoxazole compound | 上海麦克林生化科技股份有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-116283810-A | Preparation method of isoxazole compound | 上海麦克林生化科技股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| EP-2432776-B1 | METHYL SULFANYL PYRIMIDINES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS | UNIV LAVAL (CA) | 2019-09-11 | — | — | EP | disclosed |
| CN-107382820-A | A kind of synthetic method of 3 arylisoindole derivative | 常州大学 | 2017-11-24 | — | — | CN | disclosed |
| CN-104876850-B | A kind of synthetic method of isoindolinone derivatives | 常州大学 | 2017-09-08 | — | — | CN | disclosed |
| CN-105111217-B | A kind of synthetic method of iso-indoles dihydroquinazoline derivatives | 常州大学 | 2017-07-14 | — | — | CN | disclosed |
| US-9315521-B2 | Pyrimidines as novel therapeutic agents | UNIVERSITé LAVAL (CA) | 2016-04-19 | — | — | US | disclosed |
| CN-104876850-A | Isoindolinone derivative synthesis method | UNIV CHANGZHOU | 2015-09-02 | — | — | CN | disclosed |
| US-20150225423-A1 | PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS | UNIVERSITé LAVAL (CA) | 2015-08-13 | — | — | US | disclosed |
| US-20150225423-A1 | PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS | UNIVERSITé LAVAL (CA) | 2015-08-13 | — | — | US | disclosed |
| US-9040538-B2 | Pyrimidines as novel therapeutic agents | UNIVERSITE LAVAL (CA) | 2015-05-26 | — | — | US | disclosed |
| US-9040538-B2 | Pyrimidines as novel therapeutic agents | UNIVERSITE LAVAL (CA) | 2015-05-26 | — | — | US | disclosed |
| US-20100298336-A1 | PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS | UNIVERSITE LAVAL (CA) | 2010-11-25 | — | — | US | disclosed |
| US-20100298336-A1 | PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS | UNIVERSITE LAVAL (CA) | 2010-11-25 | — | — | US | disclosed |
| WO-2010132999-A1 | METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS | CHLORION PHARMA, INC. (CA) | 2010-11-25 | — | — | WO | disclosed |
| WO-2010009047-A1 | PYRIDONE DERIVATIVES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298336-A1 | PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS | TYMS, P2RX2, TYMP | ALDH1A1 577/4885MEN1 4378/4885KMT2A 3590/4885 |
| US-20150225423-A1 | PYRIMIDINES AS NOVEL THERAPEUTIC AGENTS | TYMS, P2RX2, TYMP | ALDH1A1 577/4885MEN1 4378/4885KMT2A 3590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.