SCHEMBL6903631

SCHEMBL6903631

N#Cc1cccc(C#N)c1C=O

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
TSHR P16473 1/20 0.41
MCL1 Q07820 1/20 0.40
HTT P42858 2/20 0.39
KDM4E B2RXH2 2/20 0.37
MAOA P21397 1/20 0.36
LMNA P02545 1/20 0.35
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
TERT O14746 1/20 0.34
PDK2 Q15119 1/20 0.33
MAP2K1 Q02750 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7530450 0.85 ERN1 (0.38) ALDH1A1MEN1KMT2ATDP1CA1
SCHEMBL29955549 0.85 ERN1 (0.38) ALDH1A1MEN1KMT2ATDP1CA1
SCHEMBL28162291 0.85 DYRK1A (0.41) ALDH1A1MEN1KMT2ATDP1CA1
SCHEMBL3217007 0.85 ALDH1A1 (0.61) ALDH1A1MEN1KMT2ATDP1CA1
SCHEMBL28738488 0.85 TSHR (0.54) ALDH1A1MEN1KMT2ATDP1CA1
SCHEMBL29953764 0.85 ERN1 (0.41) ALDH1A1MEN1KMT2ATDP1CA1
SCHEMBL29954526 0.85 TSHR (0.54) ALDH1A1MEN1KMT2ATDP1CA1
SCHEMBL29952167 0.80 IMPDH2 (0.47) ALDH1A1TSHRKDM4EMAOAGAA
SCHEMBL5251004 0.79 TSHR (0.44) ALDH1A1CA1CA2TSHRMCL1
SCHEMBL6897037 0.76 MEN1 (0.34) ALDH1A1MEN1KMT2ATDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1390336-A1 METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) 2004-02-25 EP claimed
WO-2002096849-A1 METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) 2002-12-05 WO claimed
EP-1390336-A1 METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) 2004-02-25 EP disclosed
WO-2002096849-A1 METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) 2002-12-05 WO disclosed