Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.50 |
| ▸ | VCP | P55072 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | GALR2 | O43603 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 2/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072427 | 0.80 | KDM4E (0.47) | PRMT1VCPMAPTALDH1A1MAPK1 | |
| SCHEMBL4074976 | 0.79 | ABCG2 (0.49) | MAPTALDH1A1MAPK1LMNAHTT | |
| SCHEMBL4307858 | 0.78 | PRMT1 (0.66) | PRMT1VCPMAPTALDH1A1MAPK1 | |
| SCHEMBL4307853 | 0.78 | PRMT1 (0.66) | PRMT1VCPMAPTALDH1A1MAPK1 | |
| SCHEMBL23493550 | 0.75 | PRMT1 (0.58) | PRMT1VCPMAPTALDH1A1MAPK1 | |
| SCHEMBL2537326 | 0.75 | PRMT1 (0.58) | PRMT1VCPMAPTALDH1A1MAPK1 | |
| SCHEMBL2537322 | 0.75 | PRMT1 (0.58) | PRMT1VCPMAPTALDH1A1MAPK1 | |
| SCHEMBL30418664 | 0.75 | PRMT1 (0.58) | PRMT1VCPMAPTALDH1A1MAPK1 | |
| SCHEMBL25297704 | 0.74 | PRMT1 (0.50) | PRMT1VCPMAPTALDH1A1MAPK1 | |
| SCHEMBL25297705 | 0.74 | PRMT1 (0.50) | PRMT1VCPMAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258173-B2 | Melatonin derivatives and their use as antioxidants | UNIVERSITY OF SUNDERLAND (GB) | 2012-09-04 | — | — | US | disclosed |
| US-20100063125-A1 | MELATONIN DERIVATIVES AND THEIR USE AS ANTIOXIDANTS | UNIVERSITY OF SUNDERLAND (GB) | 2010-03-11 | — | — | US | disclosed |
| EP-2083818-A2 | MELATONIN DERIVATIVES AND THEIR USE AS ANTIOXIDANTS | University of Sunderland (GB) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008062167-A2 | MELATONIN DERIVATIVES AND THEIR USE AS ANTIOXIDANTS | UNIVERSITY OF SUNDERLAND (GB) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063125-A1 | MELATONIN DERIVATIVES AND THEIR USE AS ANTIOXIDANTS | MTNR1A, MTNR1B, TXNRD2 | PRMT1 188/4885VCP 4512/4885MAPT 2221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.