Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.71 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.71 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.71 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.71 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.71 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.71 |
| ▸ | BACE1 | P56817 | 13/20 | 0.60 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3218671 | 1.00 | MAOB (0.71) | MAOBAKR1B1PTGS2AKR1B10GLO1 | |
| SCHEMBL9189840 | 0.84 | ENPP2 (0.75) | MAOBAKR1B1PTGS2ENPP2ABCB1 | |
| Bisdemethoxycurcumin SCHEMBL428638 | 0.84 | AKR1B1 (1.00) | MAOBAKR1B1PTGS2AKR1B10GLO1 | |
| Bisdemethoxycurcumin SCHEMBL2574140 | 0.84 | AKR1B1 (1.00) | MAOBAKR1B1PTGS2AKR1B10GLO1 | |
| SCHEMBL25190877 | 0.84 | MAOB (0.75) | MAOBPTGS2MAOA | |
| Bisdemethoxycurcumin SCHEMBL28163045 | 0.82 | AKR1B1 (0.96) | MAOBAKR1B1PTGS2AKR1B10GLO1 | |
| SCHEMBL3215468 | 0.80 | APP (0.78) | MAOBAKR1B1PTGS2GLO1CAMK2A | |
| SCHEMBL3215485 | 0.80 | APP (0.78) | MAOBAKR1B1PTGS2GLO1CAMK2A | |
| SCHEMBL10005951 | 0.80 | MAOB (0.81) | MAOBAKR1B1PTGS2AKR1B10GLO1 | |
| SCHEMBL1646481 | 0.80 | AKR1B1 (0.81) | MAOBAKR1B1PTGS2AKR1B10GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | MAOB 969/4885AKR1B1 1096/4885PTGS2 1089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.