Bisdemethoxycurcumin

Bisdemethoxycurcumin

SCHEMBL428638

O=C(/C=C/c1ccc(O)cc1)CC(=O)/C=C/c1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 3/20 1.00
AKR1B10 O60218 2/20 1.00
MAOB P27338 2/20 1.00
PTGS2 P35354 1/20 1.00
GLO1 Q04760 1/20 1.00
CAMK2A Q9UQM7 1/20 1.00
BACE1 P56817 12/20 0.73
TYR P14679 3/20 0.68
CYP2D6 P10635 1/20 0.68
CYP2C9 P11712 1/20 0.68
F3 P13726 1/20 0.68
HSD11B1 P28845 1/20 0.68
CA12 O43570 2/20 0.65
CA1 P00915 2/20 0.65
CA2 P00918 2/20 0.65
CA7 P43166 2/20 0.65
CA9 Q16790 2/20 0.65
CA14 Q9ULX7 2/20 0.65
ESR1 P03372 1/20 0.65
CA3 P07451 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bisdemethoxycurcumin SCHEMBL2574140 1.00 AKR1B1 (1.00) AKR1B1AKR1B10MAOBPTGS2GLO1
Bisdemethoxycurcumin SCHEMBL28163045 0.98 AKR1B1 (0.96) AKR1B1AKR1B10MAOBPTGS2GLO1
SCHEMBL16702807 0.92 AKR1B1 (0.85) AKR1B1AKR1B10MAOBPTGS2GLO1
SCHEMBL16702808 0.92 AKR1B1 (0.85) AKR1B1AKR1B10MAOBPTGS2GLO1
SCHEMBL23728364 0.90 AKR1B1 (0.81) AKR1B1AKR1B10MAOBPTGS2GLO1
SCHEMBL12469737 0.90 AKR1B1 (0.81) AKR1B1AKR1B10MAOBPTGS2GLO1
SCHEMBL3221765 0.90 AKR1B1 (0.81) AKR1B1AKR1B10MAOBPTGS2GLO1
SCHEMBL1646483 0.90 AKR1B1 (0.81) AKR1B1AKR1B10MAOBPTGS2GLO1
SCHEMBL12469736 0.90 AKR1B1 (0.81) AKR1B1AKR1B10MAOBPTGS2GLO1
SCHEMBL3211832 0.90 MAOB (0.81) AKR1B1AKR1B10MAOBPTGS2GLO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 705 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3829555-B1 COMPOSITIONS COMPRISING RESVERATROLOSIDES AND CURCUMIN RAVAGNAN GIAMPIETRO (IT) 2026-05-13 EP claimed
US-12601970-B2 Photosensitive resin composition, method for manufacturing patterned cured product, cured product, interlayer insulating film, cover coat layer, surface protective film, and electronic component HD MICROSYSTEMS, LTD. (JP) 2026-04-14 US claimed
EP-4633619-A1 FORMULATION COMPRISING VANILLOID POLYPHENOLS SUPPORTED ON LAMELLAR SOLIDS TO REDUCE PLASMA CGRP LEVELS AND ITS APPLICATIONS Prolabin & Tefarm S.R.L. (IT) 2025-10-22 EP claimed
US-12419930-B2 Bioavailable turmeric composition and process for preparation thereof OLENE LIFE SCIENCES PRIVATE LIMITED (IN) 2025-09-23 US claimed
US-20250262155-A1 LITHE LIPOSOMES COMPRISING ABSORPTION ENHANCERS FOR ORAL DRUG DELIVERY Aspire LLC (US) 2025-08-21 US claimed
US-20250206788-A1 CURCUMIN-PEPTIDE CONJUGATES AND FORMULATIONS THEREOF CHANCEY, John (US) 2025-06-26 US claimed
EP-3928000-B1 DIFFERENTIAL WITH BI-DIRECTIONAL OVERRUNNING CLUTCH TEAM IND INC (US) 2025-06-18 EP claimed
US-20250127731-A1 COMPOSITIONS COMPRISING CURCUMINOIDS FOR USE IN THE TREATMENT OF MUSCLE SORENESS GIVAUDAN SA (CH) 2025-04-24 US claimed
US-12247054-B2 Curcumin-peptide conjugates and formulations thereof HAUS BIOCEUTICALS, INC. 2025-03-11 US claimed
WO-2024250032-A9 SOLUBLE CURCUMIN AND ITS DERIVATIVES THERMOLIFE INTERNATIONAL, LLC (US) 2025-03-06 WO claimed
CN-104116731-A Pharmaceutical composition for preventing arteriosclerosis and preparation method thereof GUANGDONG MEDICAL COLLEGE 2014-10-29 CN claimed
CN-103800390-A Health-care product with immunity-reinforcing and liver-protecting functions, preparation method and application thereof TIANJIN TROPJOIN HEALTH TECHNOLOGY GROUP CO LTD 2014-05-21 CN claimed
US-20130316029-A1 METHODS AND COMPOSITIONS SUITABLE FOR MANAGING BLOOD GLUCOSE IN ANIMALS NESTEC S.A. (CH) 2013-11-28 US claimed
US-20130209583-A1 METHODS AND COMPOSITIONS SUITABLE FOR PROMOTING HEALTHY SKIN NESTEC S.A. (CH) 2013-08-15 US claimed
US-20100105644-A1 BOTANICAL COMPOSITION FOR ENHANCED SKIN REPAIR AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2010-04-29 US claimed
US-20090000734-A1 Method For Producing a Cladding Element INTERGLARION LIMITED (CY) 2009-01-01 US claimed
EP-1978984-A2 NUTRITIONAL SYSTEM AND METHODS FOR INCREASING LONGEVITY NESTEC S.A. (CH) 2008-10-15 EP claimed
US-20070231371-A1 Nutritional system and methods for increasing longevity NESTEC, S. A. 2007-10-04 US claimed
WO-2007088046-A2 NUTRITIONAL SYSTEM AND METHODS FOR INCREASING LONGEVITY NESTEC S.A. (CH) 2007-08-09 WO claimed
US-20030082116-A1 Adhesive compositions containing dual function stabilizers and active agents CLOSURE MEDICAL CORPORATION (US) 2003-05-01 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12601970-B2 Photosensitive resin composition, method for manufacturing patterned cured product, cured product, interlayer insulating film, cover coat layer, surface protective film, and electronic component ARCN1, P4HA1, COL1A1 AKR1B1 1232/4885AKR1B10 1091/4885MAOB 1852/4885
US-20070231371-A1 Nutritional system and methods for increasing longevity AGER, GCKR, IGFBP1 AKR1B1 869/4885AKR1B10 1332/4885MAOB 3559/4885
US-20100105644-A1 BOTANICAL COMPOSITION FOR ENHANCED SKIN REPAIR AND USES THEREOF CUTA, COL14A1, BACH1 AKR1B1 1088/4885AKR1B10 916/4885MAOB 1308/4885
US-20030082116-A1 Adhesive compositions containing dual function stabilizers and active agents TLN1, PTK2, ILK AKR1B1 4152/4885AKR1B10 3335/4885MAOB 2491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.