Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227788 | 0.94 | ALOX15 (0.51) | ALOX15ALDH1A1TSHRRECQLSIGMAR1 | |
| SCHEMBL3229268 | 0.86 | ALOX15 (0.56) | ALOX15ALDH1A1TSHRRECQLSIGMAR1 | |
| SCHEMBL19849339 | 0.81 | ALOX15 (0.59) | ALOX15ALDH1A1TSHRRECQLSMN1; SMN2 | |
| SCHEMBL13661582 | 0.79 | ALOX15 (0.61) | ALOX15ALDH1A1TSHRRECQLSIGMAR1 | |
| SCHEMBL9795126 | 0.75 | ALOX15 (0.57) | ALOX15ALDH1A1TSHRRECQLSIGMAR1 | |
| SCHEMBL9795132 | 0.75 | ALOX15 (0.57) | ALOX15ALDH1A1TSHRRECQLSIGMAR1 | |
| SCHEMBL9795359 | 0.75 | ALOX15 (0.57) | ALOX15ALDH1A1TSHRRECQLSIGMAR1 | |
| SCHEMBL3224121 | 0.75 | L3MBTL1 (0.45) | ALDH1A1TSHRSMN1; SMN2L3MBTL1CYP3A4 | |
| SCHEMBL9795189 | 0.74 | ALOX15 (0.56) | ALOX15ALDH1A1TSHRRECQLSIGMAR1 | |
| SCHEMBL9795327 | 0.74 | ALOX15 (0.56) | ALOX15ALDH1A1TSHRRECQLSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063049-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063049-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | MKI67, CCNI, CDK2 | ALOX15 1967/4885ALDH1A1 518/4885TSHR 4010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.