Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 3/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.40 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1179119 | 0.85 | PDK1 (0.67) | PDK1PDK2PDK3PDK4L3MBTL1 | |
| SCHEMBL2211292 | 0.84 | PDK1 (0.51) | PDK1PDK2PDK3PDK4PTGS2 | |
| SCHEMBL5730241 | 0.82 | PDK1 (0.50) | PDK1PDK2PDK3PDK4PTGS2 | |
| SCHEMBL5730232 | 0.81 | PDK1 (0.49) | PDK1PDK2PDK3PDK4PTGS2 | |
| SCHEMBL27724747 | 0.80 | PTGS2 (0.47) | PTGS2PTGS1AKR1B10UGT1A9TRPA1 | |
| SCHEMBL15569990 | 0.79 | PDK1 (0.55) | PDK1PDK2PDK3PDK4PTGS2 | |
| SCHEMBL4473255 | 0.78 | ALDH1A1 (0.51) | PTGS2PTGS1AKR1B10UGT1A9TRPA1 | |
| SCHEMBL14416594 | 0.76 | TSHR (0.46) | PTGS2PTGS1AKR1B10UGT1A9TRPA1 | |
| SCHEMBL12512366 | 0.76 | POLB (0.45) | PTGS2PTGS1AKR1B10UGT1A9TRPA1 | |
| SCHEMBL647689 | 0.75 | LCK (0.49) | PDK1PDK2PDK3PDK4KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010012397-A1 | N-(INDOL-3-YLALKYL)(HETERO)ARYLAMIDE DERIVATIVES AS MODULATORS OF THE EP2 RECEPTOR | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-02-04 | — | — | WO | disclosed |
| US-20100029598-A1 | Extended Benzamide Derivatives as Modulators of the EP2 Receptor | BAYER SCHERING PHARMA AG (DE) | 2010-02-04 | — | — | US | disclosed |
| EP-2149551-A1 | N-(indol-3-ylalkyl)-(hetero)arylamid derivatives as modulators of EP2 receptors | Bayer Schering Pharma AG (DE) | 2010-02-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029598-A1 | Extended Benzamide Derivatives as Modulators of the EP2 Receptor | PTGER2, PTGER1, PTGDR2 | PDK1 1842/4885PDK2 642/4885PDK3 1744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.