SCHEMBL3221735

SCHEMBL3221735

COc1ncc(C(O)c2cc(OCc3ccccc3)ccc2OC)cn1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.44
MAPK1 P28482 2/20 0.44
PDGFRB P09619 1/20 0.44
PDGFRA P16234 1/20 0.44
KDM4E B2RXH2 1/20 0.44
MAOB P27338 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.43
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
ALOX12 P18054 1/20 0.43
HSD17B10 Q99714 2/20 0.41
TSHR P16473 1/20 0.41
NPSR1 Q6W5P4 1/20 0.40
NOD2 Q9HC29 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
ACHE P22303 1/20 0.40
TUBB4A P04350 1/20 0.40
TUBB P07437 1/20 0.40
TUBA3C P0DPH7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7285420 0.86 KMT2A (0.48) MAPTMAPK1PDGFRBPDGFRAKDM4E
SCHEMBL3232630 0.82 MAPT (0.42) MAPTMAPK1PDGFRBPDGFRAKDM4E
SCHEMBL3219512 0.78 MEN1 (0.42) MAPTMAPK1PDGFRBPDGFRAKDM4E
SCHEMBL9188156 0.78 ADRA2A (0.51) MAPTMAPK1PDGFRBPDGFRAKDM4E
SCHEMBL2576276 0.77 LMNA (0.52) MAPTMAOBALDH1A1LMNA
SCHEMBL3228337 0.76 PDGFRB (0.42) MAPTMAPK1PDGFRBPDGFRAKDM4E
SCHEMBL7744533 0.76 MAOB (0.51) MAPTMAPK1MAOBL3MBTL1ALDH1A1
SCHEMBL6382820 0.75 MAOB (0.53) MAPTMAPK1PDGFRBPDGFRAMAOB
SCHEMBL9366606 0.73 LRRK2 (0.46) MAPTMAPK1PDGFRBPDGFRAKDM4E
SCHEMBL14590430 0.73 MAOB (0.56) MAPTPDGFRBPDGFRAMAOBL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040234592-A1 Mixture containing thyroid hormone , ethanolamine and emulsifier KARO BIO AB (SE) 2004-11-25 US claimed
EP-1404413-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2004-04-07 EP claimed
EP-1398024-A2 Uses for thyroid hormone compounds KARO BIO AB (SE) 2004-03-17 EP claimed
EP-0831769-B1 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KAROBIO AB (SE) 2003-10-15 EP claimed
EP-1328265-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2003-07-23 EP claimed
WO-2002089917-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2002-11-14 WO claimed
US-20020123521-A1 Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds KOO, CATHERINE, DR 2002-09-05 US claimed
US-6380255-B1 TOPICALLY APPLYING TO SKIN THYROID HORMONE COMPOUND TOGETHER WITH A BASE FOR THERAPY OF SKIN ATROPHY KARO BIO AB (SE) 2002-04-30 US claimed
WO-2002005834-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2002-01-24 WO claimed
US-6221911-B1 REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT KARO BIO AB (SE) 2001-04-24 US claimed
EP-0831769-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1998-04-01 EP claimed
WO-1996040048-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1996-12-19 WO claimed
US-20100047332-A1 Treatments for burns using thyroid hormone compound in a human KOO, CATHERINE, DR 2010-02-25 US disclosed
CN-101291640-A Thyroxine compounds for the treatment of burns and fat deposits in humans THOMAS LAVIN (US) 2008-10-22 CN disclosed
EP-0831769-B2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS LAVIN DR THOMAS N (US) 2008-07-23 EP disclosed
US-20060292194-A1 Treatment for burns and adipose deposits using thyroid hormone compound in a human KOO, CATHERINE, DR 2006-12-28 US disclosed
US-6221911-B1 REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT KARO BIO AB (SE) 2001-04-24 US disclosed
EP-0831769-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1998-04-01 EP disclosed
WO-1996040048-A9 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS 1997-03-27 WO disclosed
WO-1996040048-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1996-12-19 WO disclosed