SCHEMBL3228337

SCHEMBL3228337

COc1ccc(OCc2ccccc2)cc1C(O)c1ccc(F)nc1F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 1/20 0.42
PDGFRA P16234 1/20 0.42
MAOB P27338 1/20 0.41
MAPT P10636 4/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
ALOX12 P18054 1/20 0.41
MAPK1 P28482 2/20 0.40
KDM4E B2RXH2 2/20 0.40
ALOX5 P09917 1/20 0.40
FFAR1 O14842 5/20 0.40
PPARD Q03181 4/20 0.40
HSD17B10 Q99714 2/20 0.39
TSHR P16473 1/20 0.39
POLB P06746 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
ACHE P22303 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27586886 0.84 L3MBTL1 (0.40) PDGFRBPDGFRAMAOBMAPTL3MBTL1
SCHEMBL3221735 0.76 MAPT (0.44) PDGFRBPDGFRAMAOBMAPTL3MBTL1
SCHEMBL3219512 0.75 MEN1 (0.42) PDGFRBPDGFRAMAOBMAPTL3MBTL1
SCHEMBL9188156 0.75 ADRA2A (0.51) PDGFRBPDGFRAMAOBMAPTL3MBTL1
SCHEMBL2372021 0.75 AMY1A (0.36) MAPTALDH1A1LMNAMAPK1HSD17B10
SCHEMBL7285420 0.75 KMT2A (0.48) PDGFRBPDGFRAMAOBMAPTL3MBTL1
SCHEMBL3232630 0.75 MAPT (0.42) PDGFRBPDGFRAMAOBMAPTL3MBTL1
SCHEMBL6382820 0.72 MAOB (0.53) PDGFRBPDGFRAMAOBMAPTL3MBTL1
SCHEMBL8731416 0.72 MAPT (0.44) PDGFRBPDGFRAMAOBMAPTL3MBTL1
SCHEMBL18044481 0.71 MAOB (0.58) PDGFRBPDGFRAMAOBMAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0831769-B1 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KAROBIO AB (SE) 2003-10-15 EP claimed
EP-1328265-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2003-07-23 EP claimed
US-20020123521-A1 Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds KOO, CATHERINE, DR 2002-09-05 US claimed
US-6380255-B1 TOPICALLY APPLYING TO SKIN THYROID HORMONE COMPOUND TOGETHER WITH A BASE FOR THERAPY OF SKIN ATROPHY KARO BIO AB (SE) 2002-04-30 US claimed
WO-2002005834-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2002-01-24 WO claimed
US-6221911-B1 REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT KARO BIO AB (SE) 2001-04-24 US claimed
EP-0831769-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1998-04-01 EP claimed
WO-1996040048-A9 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS 1997-03-27 WO claimed
WO-1996040048-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1996-12-19 WO claimed
US-20100047332-A1 Treatments for burns using thyroid hormone compound in a human KOO, CATHERINE, DR 2010-02-25 US disclosed
EP-0831769-B2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS LAVIN DR THOMAS N (US) 2008-07-23 EP disclosed
WO-2007002036-A1 TYROID HORMONE IN BURN AND ADIPOSE DEPOSITES LAVIN THOMAS (US) 2007-01-04 WO disclosed
US-20060292194-A1 Treatment for burns and adipose deposits using thyroid hormone compound in a human KOO, CATHERINE, DR 2006-12-28 US disclosed
EP-1398024-A2 Uses for thyroid hormone compounds KARO BIO AB (SE) 2004-03-17 EP disclosed
US-6380255-B1 TOPICALLY APPLYING TO SKIN THYROID HORMONE COMPOUND TOGETHER WITH A BASE FOR THERAPY OF SKIN ATROPHY KARO BIO AB (SE) 2002-04-30 US disclosed
WO-2002005834-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2002-01-24 WO disclosed
US-6221911-B1 REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT KARO BIO AB (SE) 2001-04-24 US disclosed
EP-0831769-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1998-04-01 EP disclosed
WO-1996040048-A9 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS 1997-03-27 WO disclosed
WO-1996040048-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1996-12-19 WO disclosed