Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 2/20 | 0.46 |
| ▸ | AVPR1B | P47901 | 9/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 5/20 | 0.34 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3233694 | 0.94 | CENPE (0.52) | CENPEAVPR1BWNT3AKIFC1 | |
| SCHEMBL3233756 | 0.94 | CENPE (0.47) | CENPEAVPR1BDHODHKIFC1 | |
| SCHEMBL3233700 | 0.90 | CENPE (0.43) | CENPEAVPR1BWNT3AKMT2AACVR1 | |
| SCHEMBL3230227 | 0.89 | CENPE (0.49) | CENPEDHODHKIFC1 | |
| SCHEMBL3230216 | 0.89 | CENPE (0.49) | CENPEDHODHKIFC1 | |
| SCHEMBL3229432 | 0.88 | CENPE (0.49) | CENPEDHODHKIFC1 | |
| SCHEMBL3229438 | 0.88 | CENPE (0.49) | CENPEDHODHKIFC1 | |
| SCHEMBL3220019 | 0.88 | CENPE (0.48) | CENPEAVPR1BDHODHWNT3AKIFC1 | |
| SCHEMBL3220035 | 0.88 | CENPE (0.48) | CENPEAVPR1BDHODHWNT3AKIFC1 | |
| SCHEMBL3233280 | 0.88 | CENPE (0.59) | CENPEDHODHKIFC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069453-A1 | Certain Chemical Entities, Compositions, and Methods | CYTOKINETICS, INC. | 2010-03-18 | — | — | US | claimed |
| US-20070149516-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INCORPORATED | 2007-06-28 | — | — | US | claimed |
| US-20060247289-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INCORPORATED | 2006-11-02 | — | — | US | claimed |
| US-20100069453-A1 | Certain Chemical Entities, Compositions, and Methods | CYTOKINETICS, INC. | 2010-03-18 | — | — | US | disclosed |
| US-7582668-B2 | Imidazoyl-benzamide anti-cancer agents | CYTOKINETICS, INCORPORATED (US) | 2009-09-01 | — | — | US | disclosed |
| US-20070149516-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INCORPORATED | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069453-A1 | Certain Chemical Entities, Compositions, and Methods | KIF5B, KIF2C, PLK1 | CENPE 54/4885AVPR1B 4801/4885DHODH 1141/4885 |
| US-20060247289-A1 | Certain chemical entities, compositions, and methods | KIF5B, KIF2C, PLK1 | CENPE 54/4885AVPR1B 4801/4885DHODH 1141/4885 |
| US-20070149516-A1 | Certain chemical entities, compositions, and methods | KIF5B, KIF2C, PLK1 | CENPE 54/4885AVPR1B 4801/4885DHODH 1141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.