Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 8/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | VEGFA | P15692 | 2/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3208870 | 0.92 | DAO (0.47) | DAOCYP3A4KCNH2CYP2D6CYP2C9 | |
| SCHEMBL3205327 | 0.90 | DAO (0.40) | DAOCYP3A4KCNH2GPR84VEGFA | |
| SCHEMBL13457908 | 0.90 | DAO (0.40) | DAOGPR84EPAS1TUBB4ATUBB | |
| SCHEMBL3220872 | 0.90 | DAO (0.40) | DAOCYP3A4KCNH2CYP2D6CYP2C9 | |
| SCHEMBL3218219 | 0.89 | GPR84 (0.41) | DAOCYP3A4KCNH2CYP2D6CYP2C9 | |
| SCHEMBL3213769 | 0.88 | CYP19A1 (0.41) | DAOCYP3A4KCNH2CYP2D6CYP2C9 | |
| SCHEMBL3201588 | 0.85 | CYP11B1 (0.37) | DAOCYP3A4KCNH2CYP2D6CYP2C9 | |
| SCHEMBL13458259 | 0.84 | DAO (0.42) | DAOGPR84TUBB4ATUBBTUBA3C | |
| SCHEMBL3208890 | 0.83 | GRM5 (0.41) | DAOCYP3A4KCNH2CYP2D6CYP2C9 | |
| SCHEMBL3210112 | 0.81 | RAB9A (0.39) | CYP3A4KCNH2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010026075-A1 | PYRIDINE DERIVATIVES AS INHIBITORS OF HIV-I REVERSE TRANSCRIPTASE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | WO | claimed |
| US-20100056535-A1 | Inhibitors of HIV-1 reverse transcriptase | ROCHE PALO ALTO LLC | 2010-03-04 | — | — | US | claimed |
| WO-2010026075-A1 | PYRIDINE DERIVATIVES AS INHIBITORS OF HIV-I REVERSE TRANSCRIPTASE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-11 | — | — | WO | disclosed |
| US-20100056535-A1 | Inhibitors of HIV-1 reverse transcriptase | ROCHE PALO ALTO LLC | 2010-03-04 | — | — | US | disclosed |
| US-20100056535-A1 | Inhibitors of HIV-1 reverse transcriptase | ROCHE PALO ALTO LLC | 2010-03-04 | — | — | US | disclosed |
| US-20100056535-A1 | Inhibitors of HIV-1 reverse transcriptase | ROCHE PALO ALTO LLC | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056535-A1 | Inhibitors of HIV-1 reverse transcriptase | QTRT1, NQO2, QTRT2 | DAO 1380/4885CYP3A4 1165/4885KCNH2 3360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.