Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | SCD | O00767 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | FPR2 | P25090 | 3/20 | 0.48 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3201810 | 0.84 | HTR2C (0.63) | MEN1KMT2AALDH1A1GAATP53 | |
| SCHEMBL3210439 | 0.84 | MEN1 (0.57) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL3213292 | 0.83 | MAPT (0.60) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL1471602 | 0.83 | KMT2A (0.65) | MEN1KMT2ASCDSMN1; SMN2LMNA | |
| SCHEMBL3222003 | 0.83 | HTR2C (0.62) | MEN1KMT2AALDH1A1GAATP53 | |
| SCHEMBL3223665 | 0.82 | MEN1 (0.55) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL1471495 | 0.82 | TP53 (0.62) | MEN1KMT2AGAACYP2C19TP53 | |
| SCHEMBL12828374 | 0.81 | TP53 (0.48) | MEN1KMT2ATP53SCDMAPT | |
| SCHEMBL3212962 | 0.81 | PTGDR (0.57) | MEN1KMT2AALDH1A1GAATP53 | |
| SCHEMBL1471706 | 0.81 | HSD11B1 (0.54) | MEN1KMT2AALDH1A1TP53HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | MEN1 1354/4885KMT2A 1609/4885ALDH1A1 116/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | MEN1 1687/4885KMT2A 1591/4885ALDH1A1 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.