Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3210439 | 0.87 | MEN1 (0.57) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3222003 | 0.86 | HTR2C (0.62) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3213292 | 0.86 | MAPT (0.60) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3201810 | 0.85 | HTR2C (0.63) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3212962 | 0.84 | PTGDR (0.57) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3222876 | 0.83 | MCOLN3 (0.59) | SMN1; SMN2MAPTKDM4ELMNAHTT | |
| SCHEMBL24590696 | 0.83 | PTGDR (0.56) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3210436 | 0.83 | MEN1 (0.53) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3219582 | 0.82 | SCD (0.53) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3222938 | 0.82 | MEN1 (0.63) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | MEN1 1354/4885KMT2A 1609/4885SMN1; SMN2 3575/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | MEN1 1687/4885KMT2A 1591/4885SMN1; SMN2 3686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.