Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 10/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12553013 | 0.87 | CASP1 (0.40) | HIF1A | |
| SCHEMBL16456842 | 0.85 | DGAT1 (0.40) | DGAT1CHRNA7KCNH2USP30SLC6A7 | |
| SCHEMBL1929948 | 0.85 | DGAT1 (0.40) | DGAT1CHRNA7KCNH2USP30SLC6A7 | |
| SCHEMBL19856859 | 0.84 | CYP51A1 (0.40) | HTR2B | |
| SCHEMBL1549976 | 0.84 | CYP51A1 (0.40) | HTR2B | |
| SCHEMBL1550050 | 0.84 | CYP51A1 (0.40) | HTR2B | |
| SCHEMBL1550137 | 0.83 | STAT6 (0.35) | PDE10AHTR2B | |
| SCHEMBL16474120 | 0.83 | STAT6 (0.39) | HTR2B | |
| SCHEMBL1931089 | 0.83 | BRD4 (0.37) | DGAT1CTSACHRNA7KCNH2SLC6A7 | |
| SCHEMBL1932624 | 0.81 | GRIN2D (0.35) | HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2312947-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2014-01-01 | — | — | EP | disclosed |
| US-8450484-B2 | TRPV4 antagonists | GlaxoSmithKline, LLC (US) | 2013-05-28 | — | — | US | disclosed |
| WO-2010011914-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |