Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.37 |
| ▸ | IKBKB | O14920 | 4/20 | 0.37 |
| ▸ | CHUK | O15111 | 2/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8627631 | 0.81 | ALDH1A1 (0.42) | CCNA2CDK2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL2616362 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTCYP1A2HPGDGFER | |
| SCHEMBL12661728 | 0.77 | IKBKB (0.42) | CCNA2CDK2ALDH1A1MAPTLIMK1 | |
| SCHEMBL304332 | 0.77 | ALDH1A1 (0.63) | ALDH1A1MAPTCYP1A2LIMK1IKBKB | |
| SCHEMBL1477708 | 0.77 | CCNA2 (0.41) | CCNA2CDK2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL1477709 | 0.77 | CCNA2 (0.41) | CCNA2CDK2ALDH1A1MAPTLIMK1 | |
| SCHEMBL6845033 | 0.77 | CCNA2 (0.41) | CCNA2CDK2MAPTLIMK1IKBKB | |
| SCHEMBL11330712 | 0.73 | ALDH1A1 (0.41) | CDK2ALDH1A1MAPTCYP1A2LIMK1 | |
| SCHEMBL164314 | 0.73 | LMNA (0.61) | CCNA2CDK2ALDH1A1MAPTCYP1A2 | |
| SCHEMBL255872 | 0.70 | CCNA2 (0.39) | CCNA2CDK2ALDH1A1MAPTLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010007389-A1 | 5 -AMIDOTHIAZOLE DERIVATIVES AND THEIR USE AS CHECKPOINT KINASE INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010007389-A1 | 5 -AMIDOTHIAZOLE DERIVATIVES AND THEIR USE AS CHECKPOINT KINASE INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2010-01-21 | — | — | WO | disclosed |