Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 6/20 | 0.43 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | DRD2 | P14416 | 5/20 | 0.43 |
| ▸ | HTR7 | P34969 | 5/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | KIF18A | Q8NI77 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3218488 | 0.88 | HRH4 (0.49) | HRH4HTR2CMALT1HTR6HTR1A | |
| SCHEMBL3201988 | 0.87 | MALT1 (0.46) | HRH4HTR2CMALT1HTR6GBA1 | |
| SCHEMBL3219594 | 0.85 | HRH4 (0.49) | HRH4HTR2CMALT1HTR6GBA1 | |
| SCHEMBL3214389 | 0.82 | MALT1 (0.56) | MALT1HSD11B1KIF18A | |
| SCHEMBL3219593 | 0.80 | HSD11B1 (0.51) | MALT1HTR6HTR1ADRD2HTR7 | |
| SCHEMBL3218107 | 0.78 | HRH4 (0.49) | HRH4HTR2CMALT1GBA1HSD11B1 | |
| SCHEMBL3223500 | 0.77 | HSD11B1 (0.70) | HSD11B1 | |
| SCHEMBL3202120 | 0.77 | KDM4E (0.52) | MALT1HTR1ADRD2HTR7HSD11B1 | |
| SCHEMBL3223172 | 0.77 | ALDH1A1 (0.54) | HSD11B1KIF18AGRM5 | |
| SCHEMBL3221937 | 0.73 | HSD11B1 (0.51) | MALT1HSD11B1KIF18APDE10ACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | HRH4 3392/4885HTR2C 1366/4885MALT1 556/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HRH4 2530/4885HTR2C 806/4885MALT1 593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.