Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 16/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3212924 | 0.89 | HSD11B1 (0.65) | HSD11B1LMNATRPV1 | |
| SCHEMBL3213922 | 0.86 | HSD11B1 (0.67) | HSD11B1MEN1KMT2ALMNAPOLB | |
| SCHEMBL3219485 | 0.83 | HSD11B1 (0.50) | HSD11B1MEN1KMT2AMAPT | |
| SCHEMBL3198998 | 0.83 | TRPV1 (0.48) | HSD11B1MEN1KMT2ALMNATRPV1 | |
| SCHEMBL3205481 | 0.83 | HSD11B1 (0.67) | HSD11B1MEN1KMT2ATRPV1 | |
| SCHEMBL3213867 | 0.82 | KMT2A (0.51) | HSD11B1MEN1KMT2APOLBMAPT | |
| SCHEMBL3219555 | 0.82 | HSD11B1 (0.64) | HSD11B1MEN1KMT2ALMNAPOLB | |
| SCHEMBL19255971 | 0.80 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL13489663 | 0.79 | TRPV1 (0.53) | HSD11B1KMT2ALMNAPOLBTRPV1 | |
| SCHEMBL3212599 | 0.75 | HSD11B1 (1.00) | HSD11B1MEN1KMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | HSD11B1 1/4885MEN1 1354/4885KMT2A 1609/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885MEN1 1687/4885KMT2A 1591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.