Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979399 | 0.85 | HTT (0.53) | HTTALDH1A1KDM4EMITFLMNA | |
| SCHEMBL1036212 | 0.85 | GAA (0.68) | HTTALDH1A1KDM4EMITFLMNA | |
| SCHEMBL76377 | 0.84 | LMNA (0.59) | HTTALDH1A1KDM4ELMNAMAPK1 | |
| SCHEMBL1039522 | 0.83 | HTT (0.51) | HTTALDH1A1KDM4EMITFLMNA | |
| SCHEMBL4257109 | 0.83 | HTT (0.57) | HTTALDH1A1KDM4EMITFLMNA | |
| SCHEMBL20766443 | 0.83 | HTR2A (0.51) | HTTALDH1A1KDM4EMITFLMNA | |
| SCHEMBL20766387 | 0.83 | KCNQ3 (0.46) | — | |
| SCHEMBL3659918 | 0.81 | GAA (0.50) | HTTALDH1A1LMNAMAPK1GAA | |
| SCHEMBL3616256 | 0.81 | ALDH1A1 (0.53) | HTTALDH1A1LMNAGAATSHR | |
| SCHEMBL3940426 | 0.81 | HTT (0.61) | HTTALDH1A1KDM4EMITFLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036014-B | Compound with AXL inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2021-09-07 | — | — | CN | disclosed |
| WO-2018121228-A1 | COMPOUND HAVING AXL INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海药物研究所 | 2018-07-05 | — | — | WO | disclosed |
| WO-2010015587-A1 | 5-BENZYL-1,2,3,6-TETRAHYDRO-4,6-DIAZA-CYCLOPENTA[C]FLUORENE COMPOUNDS AND 5-BENZYL-1,2,3,6-TETRAHYDRO-4,6-DIAZA-CYCLOHEPTA[C]FLUORENE COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015588-A1 | BENZYL-SUBSTITUTED TETRACYCLIC HETEROCYCLIC COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |