Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3232231 | 0.92 | OPRK1 (0.37) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL2265578 | 0.89 | OPRK1 (0.43) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL2956331 | 0.88 | OPRK1 (0.44) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL2265946 | 0.88 | TP53 (0.44) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL2266190 | 0.84 | OPRK1 (0.40) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL2264547 | 0.84 | OPRK1 (0.38) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL2264625 | 0.83 | OPRK1 (0.38) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL2266008 | 0.82 | OPRK1 (0.42) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL3233295 | 0.81 | CCKBR (0.43) | LMNAALBLPAR1CHRM1CCKBR | |
| SCHEMBL4109685 | 0.81 | OPRK1 (0.53) | OPRK1PDE4DLMNAPDE3AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217576-A2 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | The Regents of the University of Michigan (US) | 2010-08-18 | — | — | EP | claimed |
| WO-2009061916-A2 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-14 | — | — | WO | claimed |