Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 9/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.39 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.39 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30713425 | 0.83 | DHODH (0.46) | DHODHPDE10AGRM2TP53HSD17B10 | |
| SCHEMBL8124347 | 0.80 | GRM2 (0.48) | DHODHPDE10AGRM2TP53HSD17B10 | |
| SCHEMBL6669896 | 0.76 | DHODH (0.41) | DHODHPDE10AGRM2TP53HSD17B10 | |
| SCHEMBL11201745 | 0.76 | GRM2 (0.42) | DHODHPDE10AGRM2 | |
| SCHEMBL61597 | 0.76 | HSD17B10 (0.52) | DHODHPDE10AGRM2TP53HSD17B10 | |
| SCHEMBL30148539 | 0.76 | HSD17B10 (0.52) | DHODHPDE10AGRM2TP53HSD17B10 | |
| SCHEMBL14238204 | 0.76 | SMN1; SMN2 (0.55) | — | |
| SCHEMBL1332157 | 0.74 | MAP2K3 (0.50) | DHODHPDE10AGRM2HSD17B10NCOA1 | |
| SCHEMBL10745356 | 0.72 | DHODH (0.54) | DHODHPDE10ATP53HSD17B10ERN1 | |
| SCHEMBL11112301 | 0.72 | TP53 (0.54) | DHODHPDE10ATP53HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399673-B2 | Substituted 2-mercaptoquinoline-3-carboxamides as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2013-03-19 | — | — | US | disclosed |
| US-20120252841-A1 | Substituted 2-mercaptoquinoline-3-carboxamides as KCNQ2/3 modulators | DRUNENTHAL GMBH (DE) | 2012-10-04 | — | — | US | disclosed |
| US-20100234372-A1 | SUBSTITUTED 2-MERCAPTOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS | GRUNENTHAL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234372-A1 | SUBSTITUTED 2-MERCAPTOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS | KCNQ1, KCNQ2, KCNJ2 | DHODH 3196/4885PDE10A 2549/4885GRM2 223/4885 |
| US-20120252841-A1 | Substituted 2-mercaptoquinoline-3-carboxamides as KCNQ2/3 modulators | KCNQ1, KCNQ2, KCNJ2 | DHODH 3196/4885PDE10A 2549/4885GRM2 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.