Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | DDX3X | O00571 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30238975 | 1.00 | TP53 (0.47) | TP53TSHRLMNACES2CES1 | |
| SCHEMBL3228242 | 1.00 | TP53 (0.47) | TP53TSHRLMNACES2CES1 | |
| SCHEMBL14243606 | 1.00 | TP53 (0.47) | TP53TSHRLMNACES2CES1 | |
| SCHEMBL20312428 | 0.80 | TSHR (0.50) | TP53TSHRLMNACES2CES1 | |
| SCHEMBL6676884 | 0.77 | TSHR (0.59) | TP53TSHRLMNACES2CES1 | |
| SCHEMBL12525632 | 0.75 | SUCNR1 (0.35) | TSHRCES2CES1ALDH1A1ALOX15 | |
| SCHEMBL20312400 | 0.74 | TSHR (0.55) | TP53TSHRLMNACES2CES1 | |
| SCHEMBL6691480 | 0.73 | TSHR (0.53) | TP53TSHRLMNACES2CES1 | |
| SCHEMBL10843264 | 0.73 | TP53 (0.50) | TP53TSHRLMNACES2CES1 | |
| SCHEMBL103381 | 0.72 | TSHR (0.52) | TP53TSHRLMNACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9573873-B2 | Catalytic method for dibenzocycloheptane synthesis and allocolchicinoid synthesis | UNIVERSITY OF WINDSOR (CA) | 2017-02-21 | — | — | US | claimed |
| EP-2952501-A2 | Anti-cancer dibenzocycloheptane derivatives and a catalytic method for dibenzocycloheptane synthesis and allocolchicinoid synthesis | University of Windsor (CA) | 2015-12-09 | — | — | EP | claimed |
| US-20150344411-A1 | Catalytic Method for Dibenzocycloheptane Synthesis and Allocolchicinoid Synthesis | UNIVERSITY OF WINDSOR (CA) | 2015-12-03 | — | — | US | claimed |
| US-9573873-B2 | Catalytic method for dibenzocycloheptane synthesis and allocolchicinoid synthesis | UNIVERSITY OF WINDSOR (CA) | 2017-02-21 | — | — | US | disclosed |
| EP-2952501-A2 | Anti-cancer dibenzocycloheptane derivatives and a catalytic method for dibenzocycloheptane synthesis and allocolchicinoid synthesis | University of Windsor (CA) | 2015-12-09 | — | — | EP | disclosed |
| US-20150344411-A1 | Catalytic Method for Dibenzocycloheptane Synthesis and Allocolchicinoid Synthesis | UNIVERSITY OF WINDSOR (CA) | 2015-12-03 | — | — | US | disclosed |
| US-20100120730-A1 | 6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO [2,3-C] QUINOLINE COMPOUNDS USEFUL AS PDE5 INHIBITORS | NYCOMED GMBH (DE) | 2010-05-13 | — | — | US | disclosed |
| WO-2010015585-A1 | 6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO[2,3-C]QUINOLINE COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015587-A1 | 5-BENZYL-1,2,3,6-TETRAHYDRO-4,6-DIAZA-CYCLOPENTA[C]FLUORENE COMPOUNDS AND 5-BENZYL-1,2,3,6-TETRAHYDRO-4,6-DIAZA-CYCLOHEPTA[C]FLUORENE COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015586-A2 | 2,3,4,7-TETRAHYDRO-INDOLO[2,3-C]QUINOLINE COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015589-A1 | BENZYL-SUBSTITUTED TETRACYCLIC HETEROCYCLIC COMPOUNDS AS PDE5 INHIBITORS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015588-A1 | BENZYL-SUBSTITUTED TETRACYCLIC HETEROCYCLIC COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |
| EP-2109610-A1 | 6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO [2, 3-C] QUINOLINE COMPOUNDS USEFUL AS PDE5 INHIBITORS | Nycomed GmbH (DE) | 2009-10-21 | — | — | EP | disclosed |
| WO-2008095835-A1 | 6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO [2, 3-C] QUINOLINE COMPOUNDS USEFUL AS PDE5 INHIBITORS | NYCOMED GMBH (DE) | 2008-08-14 | — | — | WO | disclosed |
| EP-1953159-A1 | 6-Benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]quinoline compounds useful as PDE5 inhibitors | Nycomed GmbH (DE) | 2008-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120730-A1 | 6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO [2,3-C] QUINOLINE COMPOUNDS USEFUL AS PDE5 INHIBITORS | PDE5A, PDE3A, PDE2A | TP53 4814/4885TSHR 3186/4885LMNA 2585/4885 |
| US-20150344411-A1 | Catalytic Method for Dibenzocycloheptane Synthesis and Allocolchicinoid Synthesis | RNASE1, PNLIP, AMY2A | TP53 1005/4885TSHR 4561/4885LMNA 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.