Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.61 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227948 | 0.92 | S1PR1 (0.61) | S1PR1TNNI3KMEN1KMT2AKDM4E | |
| SCHEMBL29501419 | 0.86 | MAPK10 (0.55) | S1PR1TNNI3KKDM4EMAPTALDH1A1 | |
| SCHEMBL25389479 | 0.86 | MAPK10 (0.55) | S1PR1TNNI3KKDM4EMAPTALDH1A1 | |
| SCHEMBL30443326 | 0.84 | MAPK10 (0.55) | S1PR1TNNI3KKDM4EMAPTALDH1A1 | |
| SCHEMBL25388907 | 0.84 | MAPK10 (0.55) | S1PR1TNNI3KKDM4EMAPTALDH1A1 | |
| SCHEMBL3226154 | 0.82 | S1PR1 (0.61) | S1PR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL23413101 | 0.80 | MEN1 (0.54) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL29887175 | 0.80 | MEN1 (0.54) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL23413488 | 0.79 | MAPT (0.55) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL23413150 | 0.79 | MAPT (0.53) | MEN1KMT2AKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | claimed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | claimed |