Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3226915 | 0.92 | S1PR1 (0.61) | S1PR1EGFRERBB3ALDH1A1GRM4 | |
| SCHEMBL3233015 | 0.83 | MEN1 (0.58) | S1PR1EGFRERBB3ALDH1A1USP2 | |
| SCHEMBL3228067 | 0.82 | EGFR (0.58) | S1PR1EGFRERBB3CYP1A2CYP2D6 | |
| SCHEMBL3222813 | 0.82 | EGFR (0.64) | S1PR1EGFRERBB3ALDH1A1LMNA | |
| SCHEMBL3233497 | 0.81 | KMT2A (0.51) | S1PR1EGFRERBB3ALDH1A1USP2 | |
| SCHEMBL25389479 | 0.81 | MAPK10 (0.55) | S1PR1EGFRERBB3ALDH1A1JAK2 | |
| SCHEMBL29501419 | 0.81 | MAPK10 (0.55) | S1PR1EGFRERBB3ALDH1A1JAK2 | |
| SCHEMBL25388907 | 0.81 | MAPK10 (0.55) | S1PR1EGFRERBB3ALDH1A1HSD17B10 | |
| SCHEMBL30443326 | 0.81 | MAPK10 (0.55) | S1PR1EGFRERBB3ALDH1A1HSD17B10 | |
| SCHEMBL3229185 | 0.79 | EGFR (0.57) | S1PR1EGFRERBB3ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | claimed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | claimed |