Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CETP | P11597 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11043074 | 0.91 | L3MBTL1 (0.52) | GAAL3MBTL1TDP1HDAC3HDAC1 | |
| SCHEMBL3227555 | 0.84 | HDAC1 (0.76) | HDAC3HDAC1HDAC2HDAC10HDAC4 | |
| SCHEMBL10970214 | 0.84 | L3MBTL1 (0.55) | L3MBTL1TDP1HDAC3HDAC1HDAC2 | |
| SCHEMBL27757715 | 0.84 | HDAC1 (0.62) | HDAC3HDAC1HDAC2NCOR2POLB | |
| SCHEMBL7569415 | 0.82 | KDM4E (0.60) | GAAL3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL7522106 | 0.82 | GAA (0.67) | GAAL3MBTL1TDP1HDAC3HDAC1 | |
| SCHEMBL22722430 | 0.82 | POLB (0.61) | GAAL3MBTL1TDP1HDAC3HDAC1 | |
| SCHEMBL14984048 | 0.80 | GAA (0.72) | GAAL3MBTL1TDP1HDAC3HDAC1 | |
| SCHEMBL1237373 | 0.80 | GAA (0.72) | GAAL3MBTL1TDP1HDAC3HDAC1 | |
| SCHEMBL27736940 | 0.80 | HDAC3 (0.78) | L3MBTL1HDAC3HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |