Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12508295 | 0.84 | KCNA5 (0.71) | KCNA5CYP3A4NPSR1CYP2D6CYP2C9 | |
| SCHEMBL19903410 | 0.81 | KCNA5 (0.46) | KCNA5CYP3A4NPSR1CYP2D6CYP2C9 | |
| SCHEMBL3264000 | 0.76 | KCNA5 (0.44) | KCNA5CYP3A4NPSR1CYP2D6CYP2C9 | |
| SCHEMBL24723410 | 0.75 | MGLL (0.49) | KCNA5MGLLMEN1KMT2AALDH1A1 | |
| SCHEMBL1927515 | 0.75 | LTA4H (0.49) | CYP3A4NPSR1CYP2D6CYP2C19MGLL | |
| SCHEMBL1927517 | 0.75 | LTA4H (0.49) | CYP3A4NPSR1CYP2D6CYP2C19MGLL | |
| SCHEMBL1927983 | 0.75 | LTA4H (0.49) | CYP3A4NPSR1CYP2D6CYP2C19MGLL | |
| SCHEMBL30206304 | 0.75 | LTA4H (0.49) | CYP3A4NPSR1CYP2D6CYP2C19MGLL | |
| SCHEMBL3236859 | 0.71 | ALDH1A1 (0.55) | CYP3A4CYP2C19HTTMGLLMEN1 | |
| SCHEMBL17774408 | 0.69 | ALDH1A1 (0.60) | KCNA5CYP2D6MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |