Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.47 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.45 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.45 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.45 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235305 | 0.93 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1L3MBTL1GUCY1B2 | |
| SCHEMBL3231934 | 0.92 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9ANPC1L3MBTL1GUCY1B2 | |
| SCHEMBL3236174 | 0.92 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9ANPC1L3MBTL1SCN9A | |
| SCHEMBL3228934 | 0.92 | L3MBTL1 (0.49) | SMN1; SMN2RAB9ANPC1L3MBTL1SCN9A | |
| SCHEMBL3233489 | 0.90 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9ANPC1L3MBTL1SCN9A | |
| SCHEMBL3233720 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1L3MBTL1GUCY1B2 | |
| SCHEMBL3229972 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ANPC1L3MBTL1GUCY1B2 | |
| SCHEMBL3230851 | 0.85 | FFAR2 (0.50) | SMN1; SMN2RAB9ANPC1L3MBTL1GUCY1B2 | |
| SCHEMBL3238456 | 0.85 | L3MBTL1 (0.51) | SMN1; SMN2RAB9ANPC1L3MBTL1GUCY1B2 | |
| SCHEMBL3238419 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9ANPC1L3MBTL1GUCY1B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |