Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5585691 | 0.91 | SIGMAR1 (0.31) | HSD11B1HSD11B2SIGMAR1 | |
| SCHEMBL5585942 | 0.85 | S1PR1 (0.30) | S1PR1S1PR3S1PR5 | |
| SCHEMBL5585326 | 0.81 | OPRM1 (0.31) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL3160031 | 0.81 | HSD11B1 (0.33) | HSD11B1HSD11B2S1PR1S1PR3S1PR5 | |
| SCHEMBL5671355 | 0.81 | SIRT2 (0.37) | S1PR1S1PR3S1PR5OPRM1OPRD1 | |
| SCHEMBL15557803 | 0.81 | SIRT2 (0.37) | S1PR1S1PR3S1PR5OPRM1OPRD1 | |
| SCHEMBL23251421 | 0.79 | S1PR1 (0.31) | S1PR1S1PR3S1PR5S1PR4SIGMAR1 | |
| SCHEMBL25758816 | 0.78 | MAPT (0.39) | L3MBTL1 | |
| SCHEMBL5586058 | 0.78 | — | — | |
| SCHEMBL5586003 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100178333-A1 | SUSTAINED RELEASE DOSAGE FORM OF PHENOTHIAZINE DERIVATIVES CONTAINING CHANNELIZER | ASTRON RESEARCH LIMITED (IN) | 2010-07-15 | — | — | US | disclosed |
| EP-1976487-A2 | SUSTAINED RELEASE DOSAGE FORM OF PHENOTHIAZINE DERIVATIVES CONTAINING CHANNELIZER | Astron Research Limited (IN) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007086079-A2 | SUSTAINED RELEASE DOSAGE FORM OF PHENOTHIAZINE DERIVATIVES CONTAINING CHANNELIZER | ASTRON RESEARCH LIMITED (IN) | 2007-08-02 | — | — | WO | disclosed |
| US-4933346-A | CARDIOVASCULAR AND CEREBROVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-12 | — | — | US | disclosed |
| US-4918073-A | CALCIUM ANTAGONISTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-04-17 | — | — | US | disclosed |