Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | CASP2 | P42575 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30433221 | 0.85 | TSHR (0.59) | TSHRHDAC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL3240216 | 0.84 | TSHR (0.58) | TSHRHDAC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL9010814 | 0.83 | TSHR (0.56) | TSHRHDAC1ALDH1A1CASP3CASP2 | |
| SCHEMBL4043837 | 0.81 | MEN1 (0.68) | TSHRHDAC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL9010792 | 0.75 | TSHR (0.55) | TSHRHDAC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL29528205 | 0.74 | CTSC (0.56) | TSHRHDAC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL3127881 | 0.74 | HDAC1 (0.62) | TSHRHDAC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL11985614 | 0.74 | TSHR (0.54) | TSHRHDAC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL9010904 | 0.72 | TSHR (0.51) | TSHRHDAC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL28533635 | 0.72 | TSHR (0.51) | TSHRHDAC1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247409-B2 | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use | AMGEN INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-7745449-B2 | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use | AMGEN INC. (US) | 2010-06-29 | — | — | US | disclosed |
| US-20100125074-A1 | Thieno-[2,3-d]Pyrimidine and Thieno-Pyridazine Compounds and Methods of Use | AMGEN INC. (US) | 2010-05-20 | — | — | US | disclosed |
| EP-2038289-A2 | THIENO-[2,3-D]PYRIMIDINE AND THIENO-PYRIDAZINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| US-20080032988-A1 | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use | AMGEN INC. (US) | 2008-02-07 | — | — | US | disclosed |
| WO-2007124181-A2 | THIENO-[2,3-D]PYRIMIDINE AND THIENO-PYRIDAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080032988-A1 | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use | CDK2, TBXA2R, TBXAS1 | TSHR 1134/4885HDAC1 3291/4885ALDH1A1 1576/4885 |
| US-20100125074-A1 | Thieno-[2,3-d]Pyrimidine and Thieno-Pyridazine Compounds and Methods of Use | CDK2, TBXA2R, TBXAS1 | TSHR 1134/4885HDAC1 3291/4885ALDH1A1 1576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.