Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238099 | 0.90 | HPGD (0.41) | CCR5TP53KMT2AKDM4EMEN1 | |
| SCHEMBL3230733 | 0.84 | LTA4H (0.40) | TP53KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL3233338 | 0.84 | SMN1; SMN2 (0.41) | TP53KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL3231470 | 0.82 | TP53 (0.48) | MAPTTP53KMT2AKDM4EMEN1 | |
| SCHEMBL3230749 | 0.78 | SMN1; SMN2 (0.40) | TP53KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL3228904 | 0.78 | MAPT (0.53) | MAPTTP53KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3235310 | 0.77 | SMN1; SMN2 (0.42) | MAPTCCR5TP53KMT2APOLB | |
| SCHEMBL3238419 | 0.74 | SMN1; SMN2 (0.46) | KMT2AKDM4EMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL3231465 | 0.73 | ALDH1A1 (0.44) | MAPTTP53ALDH1A1LMNAPOLB | |
| SCHEMBL3231553 | 0.72 | SMN1; SMN2 (0.46) | MAPTTP53KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |