Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3233338 | 0.94 | SMN1; SMN2 (0.41) | SMN1; SMN2HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL3230733 | 0.91 | LTA4H (0.40) | SMN1; SMN2HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL3238398 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL3231465 | 0.85 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1ALOX15TP53ADORA3 | |
| SCHEMBL3233489 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL3238099 | 0.84 | HPGD (0.41) | SMN1; SMN2HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL3230139 | 0.78 | MAPT (0.42) | SMN1; SMN2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL3238419 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL3231470 | 0.77 | TP53 (0.48) | SMN1; SMN2HPGDKDM4EMEN1ALDH1A1 | |
| SCHEMBL3235310 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2KMT2ATP53LTA4HS1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |