Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3042550 | 0.84 | PDE4A (0.43) | PDE4AALDH1A1 | |
| SCHEMBL5069379 | 0.81 | PDE4A (0.46) | PDE4AALDH1A1 | |
| SCHEMBL2565999 | 0.81 | PDE4A (0.46) | PDE4AALDH1A1 | |
| SCHEMBL1348404 | 0.79 | — | — | |
| SCHEMBL18884432 | 0.65 | — | — | |
| SCHEMBL24230139 | 0.65 | PDE4A (0.35) | PDE4AALDH1A1 | |
| SCHEMBL3331157 | 0.64 | MEN1 (0.36) | — | |
| SCHEMBL3057008 | 0.64 | — | — | |
| SCHEMBL16233238 | 0.64 | PDE4A (0.30) | PDE4A | |
| SCHEMBL2229070 | 0.64 | PDE4A (0.33) | PDE4AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745642-B2 | Glycine transport inhibitors | GLAXO GROUP LIMITED (GB) | 2010-06-29 | — | — | US | disclosed |
| US-20100137428-A1 | OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS | GLAXO GROUP LIMITED | 2010-06-03 | — | — | US | disclosed |
| EP-1833811-B1 | OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS | GLAXO GROUP LTD (GB) | 2010-06-02 | — | — | EP | disclosed |
| US-20090286828-A1 | 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2009-11-19 | — | — | US | disclosed |
| US-20090227629-A1 | COMPOUNDS HAVING ACTIVITY AT THE GLYCINE TRANSPORTER GLYT1 AND USES THEREOF | GLAXO GROUP LIMITED | 2009-09-10 | — | — | US | disclosed |
| EP-2013173-A2 | PYRIDINE-, ISOXAZOLE, THIOPHENECARBOXAMIDE COMPOUNDS HAVING ACTIVITY AT THE GLYCINE TRANSPORTER GLYT1 AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2009-01-14 | — | — | EP | disclosed |
| US-20080287547-A1 | Glycine Transport Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| WO-2007147834-A1 | GLYCINE TRANSPORTER INHIBITING COMPOUNDS AND USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007147836-A1 | GLYCINE TRANSPORTER INHIBITING COMPOUNDS AND USES IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-12-27 | — | — | WO | disclosed |
| EP-1846375-A1 | 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-10-24 | — | — | EP | disclosed |
| EP-1841727-A1 | GLYCINE TRANSPORT INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-10-10 | — | — | EP | disclosed |
| EP-1833811-A1 | OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-09-19 | — | — | EP | disclosed |
| WO-2007080159-A2 | PYRIDINE-, ISOXAZOLE, THIOPHENECARBOXAMIDE COMPOUNDS HAVING ACTIVITY AT THE GLYCINE TRANSPORTER GLYT1 AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2007-07-19 | — | — | WO | disclosed |
| WO-2006067430-A1 | 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |
| WO-2006067437-A1 | OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |
| WO-2006067423-A1 | GLYCINE TRANSPORT INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286828-A1 | 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES | PNMT, SLC18A2, COMT | PDE4A 345/4885ALDH1A1 132/4885 |
| US-20090227629-A1 | COMPOUNDS HAVING ACTIVITY AT THE GLYCINE TRANSPORTER GLYT1 AND USES THEREOF | SLC18A2, SLC6A3, SLC6A2 | PDE4A 2331/4885ALDH1A1 777/4885 |
| US-20100137428-A1 | OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS | SLC18A2, SLC1A2, SLC6A3 | PDE4A 2323/4885ALDH1A1 483/4885 |
| US-20080287547-A1 | Glycine Transport Inhibitors | SLC18A2, SLC6A5, SLC1A2 | PDE4A 2387/4885ALDH1A1 1356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.