Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243661 | 0.88 | PSMB5 (0.42) | EPHX2PRMT6CHRNB2CHRNA4PSMB5 | |
| SCHEMBL3245741 | 0.86 | PRKCI (0.50) | PRMT6CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL3239914 | 0.84 | CHRNB2 (0.67) | CHRNB2CHRNA4LMNAMAPK1ALDH1A1 | |
| SCHEMBL3245933 | 0.81 | CLK4 (0.40) | BACE1ALDH1A1CETPCYP2D6CYP2C19 | |
| SCHEMBL30093157 | 0.76 | CHRNB2 (0.79) | CHRNB2CHRNA4LMNAMAPK1ALDH1A1 | |
| SCHEMBL30866167 | 0.73 | EPHX2 (0.63) | EPHX2PRMT6CYP2A6LMNAMKNK1 | |
| SCHEMBL4163500 | 0.73 | EPHX2 (0.63) | EPHX2PRMT6CYP2A6LMNAMKNK1 | |
| SCHEMBL2759632 | 0.73 | EPHX2 (0.68) | EPHX2PRMT6CYP2A6MKNK1MKNK2 | |
| SCHEMBL19147333 | 0.72 | EPHX2 (0.58) | EPHX2PRMT6CYP2A6MKNK1MKNK2 | |
| SCHEMBL3245740 | 0.72 | HRH3 (0.42) | PRMT6CHRNB2CHRNA4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | EPHX2 1245/4885PRMT6 3989/4885CHRNB2 3688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.