Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PYCR1 | P32322 | 3/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.37 |
| ▸ | TEK | Q02763 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243661 | 0.85 | PSMB5 (0.42) | JAK1ATMTAAR1CHRNB2CHRNA4 | |
| SCHEMBL3236491 | 0.83 | SMN1; SMN2 (0.46) | HRH3PYCR1TAAR1LSS | |
| SCHEMBL448352 | 0.80 | ATM (0.56) | ATMEPHB4TEKKDRGRM2 | |
| SCHEMBL6852160 | 0.74 | ATM (0.50) | ATMEPHB4TEKKDRGRM2 | |
| SCHEMBL3242981 | 0.73 | ADRB2 (0.49) | HRH3PYCR1TAAR1 | |
| SCHEMBL3239914 | 0.73 | CHRNB2 (0.67) | CHRNB2CHRNA4MAPK1 | |
| SCHEMBL3242409 | 0.72 | ALDH1A1 (0.54) | HRH3PYCR1TAAR1PRMT6 | |
| SCHEMBL3233011 | 0.72 | EPHX2 (0.52) | CHRNB2CHRNA4MAPK1PRMT6 | |
| SCHEMBL3235955 | 0.71 | PYCR1 (0.41) | PYCR1CHRNB2CHRNA4 | |
| SCHEMBL3245741 | 0.71 | PRKCI (0.50) | HRH3TAAR1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | HRH3 2578/4885JAK1 2033/4885ATM 2713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.