Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3225870 | 0.92 | LMNA (0.44) | HTTNAMPTKMT2AMEN1CHRNB2 | |
| SCHEMBL3235821 | 0.87 | KMT2A (0.46) | HTTKMT2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3236377 | 0.78 | CHRNB2 (0.45) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL3228729 | 0.76 | CHRNB2 (0.58) | KMT2AMEN1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3236539 | 0.75 | CHRNB2 (0.56) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL1711252 | 0.74 | CHRNB2 (0.55) | HTTKMT2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8312649 | 0.73 | HTT (0.56) | HTTTDP1NAMPTKMT2AMEN1 | |
| SCHEMBL3240417 | 0.73 | CHRNB2 (0.52) | KMT2AMEN1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL3236313 | 0.73 | CHRNB2 (0.43) | HTTKMT2AMEN1CHRNB2CHRNB4 | |
| SCHEMBL3235786 | 0.72 | CHRNB2 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028011-A1 | AMIDES OF DIAZABICYCLONONANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | claimed |
| WO-2010028011-A1 | AMIDES OF DIAZABICYCLONONANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | disclosed |