Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242088 | 0.86 | POLQ (0.44) | HDAC1HDAC3HDAC6HDAC2HDAC4 | |
| SCHEMBL3236792 | 0.86 | HDAC1 (0.42) | HDAC1HDAC3HDAC6HDAC2HDAC4 | |
| SCHEMBL3241080 | 0.84 | MPO (0.40) | HDAC1HDAC3MPO | |
| SCHEMBL3236511 | 0.80 | HDAC3 (0.38) | HDAC1HDAC3HDAC6HDAC2MPO | |
| SCHEMBL3230365 | 0.79 | HDAC1 (0.43) | HDAC1HDAC3MPOALDH1A1LMNA | |
| SCHEMBL3263676 | 0.78 | MPO (0.35) | HDAC1HDAC3MPO | |
| SCHEMBL3265770 | 0.76 | HDAC1 (0.38) | HDAC1HDAC3LMNA | |
| SCHEMBL3235377 | 0.76 | HDAC3 (0.42) | HDAC1HDAC3HDAC2MPOALDH1A1 | |
| SCHEMBL3236799 | 0.76 | LMNA (0.44) | HDAC1ALDH1A1KDM4ELMNARAB9A | |
| SCHEMBL3241850 | 0.75 | HDAC1 (0.34) | HDAC1HDAC3HDAC2MPOKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |