Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.37 |
| ▸ | GLRB | P48167 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235218 | 0.93 | CHRM1 (0.44) | CHRM1FABP4P2RX7RORCS1PR1 | |
| SCHEMBL3238408 | 0.88 | CHRM1 (0.46) | CHRM1FABP4RORC | |
| SCHEMBL3233936 | 0.88 | CHRM1 (0.46) | CHRM1P2RX7TP53ATMMAPT | |
| SCHEMBL3238772 | 0.86 | CHRM1 (0.44) | CHRM1FABP4FABP3P2RX7RORC | |
| SCHEMBL3234278 | 0.86 | CHRM1 (0.64) | CHRM1FABP4FABP3RORCS1PR1 | |
| SCHEMBL3234555 | 0.86 | CHRM1 (0.49) | CHRM1P2RX7TP53MAPT | |
| SCHEMBL3234252 | 0.84 | CHRM1 (0.44) | CHRM1P2RX7RORCTP53MAPT | |
| SCHEMBL3234399 | 0.83 | CHRM1 (0.63) | CHRM1TP53HTTNPSR1MAPT | |
| SCHEMBL3234592 | 0.82 | ALDH1A1 (0.51) | CHRM1RORCKDM4EMEN1TSHR | |
| SCHEMBL3239684 | 0.82 | CHRM1 (0.52) | CHRM1P2RX7POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |