Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20913316 | 0.98 | KMT2A (0.41) | KMT2ANPC1MEN1KDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL2729014 | 0.97 | KMT2A (0.40) | KMT2ANPC1MEN1KDM4ERAB9A | |
| Bromide SCHEMBL3234832 | 0.76 | ALDH1A1 (0.43) | KMT2ANPC1MEN1KDM4ERAB9A | |
| SCHEMBL8103360 | 0.75 | MAPT (0.48) | KMT2ANPC1MEN1KDM4ERAB9A | |
| SCHEMBL20913315 | 0.74 | MAPT (0.44) | KMT2ANPC1MEN1KDM4ERAB9A | |
| Iodide SCHEMBL5949218 | 0.74 | MAPT (0.47) | KMT2ANPC1MEN1KDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL2729011 | 0.73 | KDM4E (0.43) | KMT2ANPC1MEN1KDM4ERAB9A | |
| SCHEMBL6560513 | 0.72 | NPC1 (0.59) | KMT2ANPC1MEN1KDM4ERAB9A | |
| Iodide SCHEMBL5949442 | 0.71 | NPC1 (0.57) | KMT2ANPC1MEN1KDM4ERAB9A | |
| Bromide SCHEMBL6010154 | 0.71 | KMT2A (0.47) | KMT2ANPC1MEN1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150051161-A1 | Methods for the Detection of Advanced Glycation Endproducts and Markers for Disease | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-02-19 | — | — | US | disclosed |
| US-20110319499-A1 | Methods for the Detection of Advanced Glycation Endproducts and Markers for Disease | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-12-29 | — | — | US | disclosed |
| WO-2010005531-A2 | METHODS FOR THE DETECTION OF ADVANCED GLYCATION ENDPRODUCTS AND MARKERS FOR DISEASE | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-01-14 | — | — | WO | disclosed |