Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20913316 | 0.98 | KMT2A (0.41) | KMT2ANPC1MEN1KDM4EMAPT | |
| Bromide SCHEMBL3234835 | 0.97 | KMT2A (0.40) | KMT2ANPC1MEN1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL2729011 | 0.76 | KDM4E (0.43) | KMT2ANPC1MEN1KDM4EMAPT | |
| SCHEMBL8103360 | 0.75 | MAPT (0.48) | KMT2ANPC1MEN1KDM4EMAPT | |
| SCHEMBL20913315 | 0.74 | MAPT (0.44) | KMT2ANPC1MEN1KDM4EMAPT | |
| Iodide SCHEMBL5949218 | 0.74 | MAPT (0.47) | KMT2ANPC1MEN1KDM4EMAPT | |
| Bromide SCHEMBL3234832 | 0.73 | ALDH1A1 (0.43) | KMT2ANPC1MEN1KDM4EMAPT | |
| SCHEMBL6560513 | 0.72 | NPC1 (0.59) | KMT2ANPC1MEN1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL15262009 | 0.71 | KMT2A (0.43) | KMT2ANPC1MEN1KDM4EMAPT | |
| Iodide SCHEMBL5949442 | 0.71 | NPC1 (0.57) | KMT2ANPC1MEN1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2685987-B1 | COMPOSITIONS AND METHODS USEFUL FOR AMELIORATING AGE RELATED MALADIES | NESTEC SA (CH) | 2019-04-24 | — | — | EP | claimed |
| US-10010566-B2 | Compositions and methods useful for ameliorating age related maladies | NestecSA (CH) | 2018-07-03 | — | — | US | claimed |
| US-9301973-B2 | Methods and compositions suitable for promoting healthy skin | NESTEC S.A. (CH) | 2016-04-05 | — | — | US | claimed |
| EP-2685987-A2 | COMPOSITIONS AND METHODS USEFUL FOR AMELIORATING AGE RELATED MALADIES | Nestec S.A. (CH) | 2014-01-22 | — | — | EP | claimed |
| US-20140004205-A1 | COMPOSITIONS AND METHODS USEFUL FOR AMELIORATING AGE RELATED MALADIES | NESTEC SA (CH) | 2014-01-02 | — | — | US | claimed |
| EP-2654777-A2 | METHODS AND COMPOSITIONS SUITABLE FOR MANAGING BLOOD GLUCOSE IN ANIMALS | Nestec S.A. (CH) | 2013-10-30 | — | — | EP | claimed |
| EP-2632414-A1 | METHODS AND COMPOSITIONS SUITABLE FOR PROMOTING HEALTHY SKIN | Nestec S.A. (CH) | 2013-09-04 | — | — | EP | claimed |
| US-20130209583-A1 | METHODS AND COMPOSITIONS SUITABLE FOR PROMOTING HEALTHY SKIN | NESTEC S.A. (CH) | 2013-08-15 | — | — | US | claimed |
| WO-2012128982-A2 | COMPOSITIONS AND METHODS USEFUL FOR AMELIORATING AGE RELATED MALADIES | NESTEC S.A. (CH) | 2012-09-27 | — | — | WO | claimed |
| WO-2012087742-A2 | METHODS AND COMPOSITIONS SUITABLE FOR MANAGING BLOOD GLUCOSE IN ANIMALS | NESTEC S.A. (CH) | 2012-06-28 | — | — | WO | claimed |
| WO-2012057824-A1 | METHODS AND COMPOSITIONS SUITABLE FOR PROMOTING HEALTHY SKIN | NESTEC S.A. (CH) | 2012-05-03 | — | — | WO | claimed |
| EP-2685987-B1 | COMPOSITIONS AND METHODS USEFUL FOR AMELIORATING AGE RELATED MALADIES | NESTEC SA (CH) | 2019-04-24 | — | — | EP | disclosed |
| US-10010566-B2 | Compositions and methods useful for ameliorating age related maladies | NestecSA (CH) | 2018-07-03 | — | — | US | disclosed |
| CN-103282013-B | It is suitable for the method and composition of sanatory skin | 雀巢产品技术援助有限公司 | 2016-10-26 | — | — | CN | disclosed |
| US-9301973-B2 | Methods and compositions suitable for promoting healthy skin | NESTEC S.A. (CH) | 2016-04-05 | — | — | US | disclosed |
| EP-2632414-A1 | METHODS AND COMPOSITIONS SUITABLE FOR PROMOTING HEALTHY SKIN | Nestec S.A. (CH) | 2013-09-04 | — | — | EP | disclosed |
| CN-103282013-A | Methods and compositions suitable for promoting healthy skin | NESTEC SA | 2013-09-04 | — | — | CN | disclosed |
| US-20130209583-A1 | METHODS AND COMPOSITIONS SUITABLE FOR PROMOTING HEALTHY SKIN | NESTEC S.A. (CH) | 2013-08-15 | — | — | US | disclosed |
| WO-2012128982-A2 | COMPOSITIONS AND METHODS USEFUL FOR AMELIORATING AGE RELATED MALADIES | NESTEC S.A. (CH) | 2012-09-27 | — | — | WO | disclosed |
| WO-2012057824-A1 | METHODS AND COMPOSITIONS SUITABLE FOR PROMOTING HEALTHY SKIN | NESTEC S.A. (CH) | 2012-05-03 | — | — | WO | disclosed |