Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18410572 | 0.83 | LMNA (0.46) | NPC1RAB9AMAPTLMNA | |
| SCHEMBL323498 | 0.82 | MMP13 (0.43) | ALDH1A1CYP2D6KMT2ASTAT3 | |
| SCHEMBL18410574 | 0.77 | LMNA (0.49) | P2RX4NPC1RAB9AMAPTLMNA | |
| SCHEMBL18396809 | 0.77 | STAT3 (0.45) | ALDH1A1CYP2D6KMT2ASTAT3KDM4E | |
| SCHEMBL30586531 | 0.76 | MMP13 (0.46) | ALDH1A1CYP2D6KMT2ASTAT3 | |
| SCHEMBL5968033 | 0.75 | ALDH1A1 (0.41) | ALDH1A1CYP2D6KMT2ANPC1RAB9A | |
| SCHEMBL20328797 | 0.74 | LMNA (0.46) | NPC1RAB9AMAPTGAALMNA | |
| SCHEMBL5968035 | 0.73 | CHRM2 (0.41) | ALDH1A1CYP2D6KMT2ANPC1RAB9A | |
| SCHEMBL3951270 | 0.73 | CYP2D6 (0.56) | ALDH1A1CYP2D6KMT2ANPC1RAB9A | |
| SCHEMBL26361860 | 0.73 | MMP13 (0.45) | ALDH1A1CYP2D6KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590953-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004604-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2012-01-12 | — | — | WO | disclosed |