Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | DBH | P09172 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236790 | 0.90 | CHRM1 (0.53) | CHRM1P2RX7SMN1; SMN2 | |
| SCHEMBL2880256 | 0.86 | CHRM1 (0.76) | CHRM1TDP1DBHP2RX7ALKBH1 | |
| SCHEMBL3235484 | 0.85 | CHRM1 (0.52) | CHRM1TDP1DBHP2RX7ROCK2 | |
| SCHEMBL3234654 | 0.85 | CHRM1 (0.57) | CHRM1SMN1; SMN2LMNA | |
| SCHEMBL3239024 | 0.84 | CHRM1 (0.57) | CHRM1SMN1; SMN2 | |
| SCHEMBL2487847 | 0.84 | CHRM1 (0.70) | CHRM1P2RX7SMN1; SMN2LMNA | |
| SCHEMBL3239724 | 0.83 | CHRM1 (0.50) | CHRM1P2RX7SMN1; SMN2 | |
| SCHEMBL2486079 | 0.81 | CHRM1 (0.70) | CHRM1 | |
| SCHEMBL3237430 | 0.81 | CHRM1 (0.53) | CHRM1P2RX7SMN1; SMN2 | |
| SCHEMBL3236193 | 0.80 | CHRM1 (0.53) | CHRM1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |