Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3237092 | 0.89 | GAA (0.50) | TP53LMNAPOLBSMN1; SMN2MAPT | |
| SCHEMBL3236188 | 0.88 | CHRM1 (0.69) | CHRM1TP53LMNA | |
| SCHEMBL3235484 | 0.87 | CHRM1 (0.52) | CHRM1LMNASMN1; SMN2 | |
| SCHEMBL2491002 | 0.81 | CHRM1 (0.71) | CHRM1LMNAPOLBSMN1; SMN2MAPT | |
| SCHEMBL3241260 | 0.81 | TP53 (0.68) | CHRM1TP53LMNAPOLBSMN1; SMN2 | |
| SCHEMBL3240976 | 0.80 | CHRM1 (0.56) | CHRM1LMNASMN1; SMN2 | |
| SCHEMBL3237179 | 0.80 | LMNA (0.59) | CHRM1TP53LMNA | |
| SCHEMBL2490511 | 0.80 | LMNA (0.59) | CHRM1TP53LMNA | |
| SCHEMBL3234156 | 0.80 | LMNA (0.62) | CHRM1TP53LMNA | |
| SCHEMBL3241379 | 0.79 | CHRM1 (0.47) | CHRM1TP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |