Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.73 |
| ▸ | HTR2C | P28335 | 1/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.73 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.73 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSPO | P30536 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2921949 | 0.90 | OPRK1 (0.60) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL14018729 | 0.90 | OPRK1 (0.84) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL9472878 | 0.85 | OPRK1 (0.76) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL30908742 | 0.84 | OPRK1 (0.58) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL29244914 | 0.84 | OPRK1 (0.58) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| Medazepam SCHEMBL11658148 | 0.84 | OPRK1 (1.00) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| Medazepam SCHEMBL18472 | 0.84 | OPRK1 (1.00) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| Medazepam SCHEMBL29642025 | 0.84 | OPRK1 (1.00) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL2928292 | 0.83 | OPRK1 (0.51) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| Medazepam SCHEMBL78352 | 0.83 | OPRK1 (0.97) | OPRK1PDE4DNR1I2ADORA3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217576-A2 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | The Regents of the University of Michigan (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061916-A2 | BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-14 | — | — | WO | disclosed |